• It is important to know whether pilsicainide can be used

  2019-06-29

  

  It is important to know whether pilsicainide can be used as a therapeutic agent for LQT2 patients; and if so, we should determine the types of LQT2 mutation carriers to whom pilsicainide could be administered. As shown in Fig. 8, we examined the effects of pilsicainide on two mutant hERG proteins, G

• br Conclusions and future perspectives br Conflict of

  2019-06-29

  

  Conclusions and future perspectives Conflict of interest Author’s contributions Introduction Sulfotransferase (SULT)-mediated sulfation and steroid sulfatase (STS)-mediated desulfation represent two opposing mechanisms involved in regulating the chemical and functional homeostasis of end

• br Over the past decade global concern about the

  2019-06-29

  

  Over the past decade, global concern about the disproportionate burden of disease and mortality in low-income countries, especially in sub-Saharan Africa, has led to a substantial influx of funding for research by many donor and research agencies. This investment has energised in-country research;

• More than million almost children younger than years

  2019-06-29

  

  More than 200 million—almost 40%—children younger than 5 years in developing countries are not fulfilling their developmental potential. In parts of Africa, up to three-quarters of children are victims of physical abuse, and a third of girls and more than 10% of boys are victims of sexual abuse. One

• En este contexto a juicio de Svampa cohabitan

  2019-06-29

  

  En este contexto, Lithocholic Acid weight juicio de Svampa, cohabitan en el campo contestatario latinoamericano cuatro matrices político-ideológicas que dan cuenta de diferentes perspectivas en relación con la manera de pensar la política y el poder, así como los procesos de cambio social. Estas mat

• La categorizaci n propuesta por Margaret Randall es mucho

  2019-06-29

  

  La categorización propuesta por Margaret Randall es mucho más simple, puesto que distingue tan sólo entre aquellos testimonios en sí de los testimonios para sí. Christina Dupláa analiza tal distinción: Como puede verse, la clasificación es bastante difusa, ya que en la primera categoría se consider

• Romiplostim is an Fc fusion protein that augments thrombopoi

  2019-06-29

  

  Romiplostim is an Fc-fusion protein that augments thrombopoiesis by binding to and activating the thrombopoietin receptor. It is approved for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglo

• In recent years the impact that food production and consumpt

  2019-06-29

  

  In recent years, the impact that food production and consumption have had on the environment has received increasing international attention. Some food production practices and consumption behaviours are putting the environment under a great stress, contributing to climate change. The food sector ac

• Yang et al reported PSA triggered TRUSP biopsy in

  2019-06-29

  

  Yang et al. reported PSA triggered TRUSP biopsy in Korea. This study included 75 patients younger than 40 years of age, with PSA > 4.0 ng/mL; the PCa detection rate was 1.3% in the Korean study. In comparison, there were substantially more abnormal DRE findings and significant LUTS findings in our s

• Nowadays other Brazilian HIV patients were enrolled

  2019-06-29

  

  Nowadays other 20 Brazilian HIV+ patients were enrolled in the second-phase of Lu et al. clinical trial [3], and biologic samples are becoming available for novel investigation. All this considered and taken into account that the intrinsic ability of each HIV+ individual to counteract HIV-1 results

• De cualquier modo la fecha para votar la

  2019-06-28

  

  De cualquier modo, la fecha para votar la propuesta del cuatripartito latinoamericano fue programada para el 16 de mayo de 1949. Tras intensos días de discusión, donde se pudieron observar las claras diferencias existentes también entre los países de América Latina, el balance final fue de 26 votos

• br Hacia finales de los a os ochenta y

  2019-06-28

  

  Hacia finales de los años ochenta y en el contexto norteamericano, la gran mayoría de las personas que se incluían en la naciente “cultura gay” —habiéndose apropiado previamente de ese término para autodenominarse contra el patologizante apócope de homosexual— eran varones blancos, pequeños burgue

• I received a grant from The Kendeda Fund to write

  2019-06-28

  

  I received a grant from The Kendeda Fund to write and promote my book, , on which this comment is based. I thank Richard King (Chatham House, London, UK) for data assistance, Christian Guthier (All is Possible, Oxford, UK) for graphic design, and Sarah Cornell (Stockholm Resilience Centre, Stockholm

• br Introduction Acute myeloid leukemia AML remains a hematol

  2019-06-28

  

  Introduction Acute myeloid leukemia (AML) remains a hematologic malignancy with poor outcome and a high risk for relapse believed to be caused by the survival of leukemic stem cells (LSCs), which are responsible for disease repopulation following treatment [1]. This important implication of LSCs

• br Water the main component

  2019-06-28

  

  Water—the main component of Earth\'s ecosystems—concentrates some of the most worrying global concerns that have emerged during the Anthropocene. When it comes to health considered at a planetary level, the challenges related to water can be sorted into five main categories: pollution, access to w

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