• Glucose metabolic pathways are well defined but the subcellu

  2022-01-06

  

  Glucose metabolic pathways are well defined but the subcellular organization of these pathways is poorly understood in liver and kidney. Several factors affect the net flux of gluconeogenesis and allow the ace inhibitors to respond to physiological changes [1]. Ovadi and Srere have suggested that a

• In summary tail vein injection of

  2022-01-06

  

  In summary, tail vein injection of mmLDL activated the ERK1/2 signaling pathway, leading to increased serum concentrations and increased vascular wall expression of ICAM-1 and VCAM-1, and may cause increased expression of vascular smooth muscle ETB receptors and the ETB receptor-mediated contractile

• br Results and discussion Computer modelling studies suggest

  2022-01-06

  

  Results and discussion Computer modelling studies suggested that the endocyclic oxygens in furocoumarin derivatives, such as bcl-2 inhibitor 3a (Fig. 1), could also coordinate metal ions in the HIV-1 IN enzyme active site and inhibit the integration of viral DNA. The coumarin moiety is found in

• Dual H H receptor antagonists developed by GlaxoSmithKline h

  2022-01-06

  

  Dual H1/H3 receptor antagonists developed by GlaxoSmithKline have also reached clinical trials at various stages. These candidates are useful for alleviating the symptoms associated with allergic rhinitis(Daley-Yates et al., 2012). GSK-1004723, 4-[(4-chlorophenyl)methyl]-2-( (2R)-1-[4-(4- [3-(hexahy

• The therapeutic potential of acetate has been advocated by r

  2022-01-06

  

  The therapeutic potential of acetate has been advocated by research on neurodegenerative disorders such as Canavan's disease (Arun et al., 2010, Mathew et al., 2005), where oral acetate improved motor function in a genetic model of the disorder, and in studies of behavioural phenotypes associated wi

• A series of P P ureas

  2022-01-05

  

  A series of P3-P4 ureas were explored first and their anti-NS3 protease activity, antiviral properties in a HCV replicon cell-based assay and PK profiles examined. Installation of a methyl group on the P4 side nitrogen 20187 of the urea yielded , a molecule which retained intrinsic potency against

• For the study described herein analogues of CID were

  2022-01-05

  

  For the study described herein, analogues of CID1792197 (2) were selected for exploration. There are a variety of reasons for this decision. First, the synthetic approach, described hereafter, is modular in nature to rapidly enable the independent modification of either end of the molecule. Second,

• INTRODUCTION Scar formation and tissue regeneration

  2022-01-05

  

  INTRODUCTION Scar formation and tissue regeneration are opposite results of the wound healing process. Although fibrosis is more common after skin injury, full skin regeneration results in complete replacement of adnexa and function. Examples of tissue regeneration in mammalian systems include annu

• Evaluating the plausibility of this

  2022-01-05

  

  Evaluating the plausibility of this selective scenario is challenging because of the uncertainties concerning the biological role of calpain-10 and the significance of its variants with regard to gene function and disease susceptibility. However, from a strictly evolutionary standpoint, our findings

• Autophagy as an important cellular process

  2022-01-05

  

  Autophagy as an important cellular process has drawn attentions to its role in cardiovascular systems [16]. Autophagy is a self-digestion and degradation process that recycles the contents of the cytosol, including macromolecules and cellular organelles, resulting in self-repair and conservation for

• The EEGs of these six patients interestingly showed focal

  2022-01-05

  

  The EEGs of these six patients interestingly showed focal, multi-focal and generalized spikes, which was an exclusion criteria in our study as we selected our cohort to exclusively represent focal epilepsy. Remarkably all of these cases were diagnosed with paroxysmal exercise-induced dyskinesia (PED

• Up to now the research about the effect

  2022-01-05

  

  Up to now, the research about the effect of PAs on inhibiting carbohydrase activity in vitro or reducing blood sugar level in vivo was mainly reported in PAs from grape seeds, Lepisanthes alata (Malay cherry) leaves, sorghum, pomegranate, cranberry and persimmon (Banerji and Banerjee, 2016, Barrett

• In type diabetic subjects with mean baseline

  2022-01-05

  

  In type-2 diabetic subjects with mean baseline glycated hemoglobin A (HbA) of 8.4%, q.d. administration of MK-0893 for 12weeks as a monotherapy resulted in dose-dependent decreases in HbA and FPG. Administration of MK-0893 q.d. at doses of 20, 40, 60, and 80mg led to observed reductions in HbA of 0.

• br Introduction Glucose homeostasis is primarily regulated b

  2022-01-05

  

  Introduction Glucose homeostasis is primarily regulated by the hormones insulin and glucagon, secreted from the pancreatic islets of Langerhans. Although insulin produced by β ac 723 sale is the blood glucose-lowering hormone, glucagon secreted from α cells acts as the major counter-regulatory ho

• Extending time action is another strategy to

  2022-01-05

  

  Extending time action is another strategy to increase in vivo efficacy. Twice daily administration of the unacylated analogs herein caused greater body weight loss in DIO mice than the equivalent dose administered as a single daily injection, suggesting that protracted time action should yield more

15552 records 507/1037 page Previous Next First page 上5页 506507508509510 下5页 Last page