• In addition AMPK reduces protein synthesis

  2023-04-20

  

  In addition, AMPK reduces protein synthesis and stimulates apoptotic and autophagic pathways through the inhibition of the mechanistic target of rapamycin (mTOR), which regulates cellular metabolic homeostasis, insulin secretion, insulin resistance, autophagy and apoptosis (Maiese, 2016). mTOR is th

• Further validation for a role

  2023-04-20

  

  Further validation for a role in 12/15-LOX pathway in mediating adipocyte function comes from studies revealing a regulatory role of lipocalin-2 on 12/15-LOX activity. Lipocalin-2, a glycoprotein member of the lipocalin superfamily, is a novel abundant adipokine implicated in obesity-mediated inflam

• The lactam emerged as lead candidate due to its high

  2023-04-20

  

  The lactam (6) emerged as lead candidate due to its high selectivity, outstanding potency (against ALK or in clinically known ALK mutants), low in vitro clearance, and low efflux potential. The lactam (6) was selected for further profiling against the resistant ALK mutants. Preclinical rat pharmacok

• Di ethylhexyl phthalate DEHP is one of the

  2023-04-20

  

  Di-(2-ethylhexyl) phthalate (DEHP) is one of the most widely used environmental chemicals in the production of polyvinyl chloride. After Trehalose sale into human body, DEHP can be converted to the metabolite mono-ethylhexyl phthalate (MEHP), which has higher toxicity than DEHP and can influence re

• The enzyme mediated ATP sensing

  2023-04-19

  

  The enzyme-mediated ATP-sensing mechanism in zebrafish can be compared with previous studies in other animal species reporting that enzymatic conversion of chemicals in the peripheral olfactory organ results in either “activation” or “inactivation” of odorants and pheromones. In male silkmoth, the a

• br Experimental Procedures br Acknowledgments br Introductio

  2023-04-19

  

  Experimental Procedures Acknowledgments Introduction Synapses are fundamental units for efficient communication between neurons and their target cells. Despite significant progress in understanding the structure of matured synapses, less is known about the mechanisms by which neurotransmitt

• br Funding br Ethics br Conflict of interest br Acknowledgem

  2023-04-18

  

  Funding Ethics Conflict of interest Acknowledgements Introduction Hepatic fibrosis occurs in response to different etiologies of chronic liver injury, which is mainly accompanied by pathological bromophenol blue of excessive extracellular matrix (ECM) of the liver, as the common reac

• br Conflicts of interest br Acknowledgments The

  2023-04-18

  

  Conflicts of interest Acknowledgments The authors acknowledge National Institute for Medical Research Development (NIMAD) project no. 940943 and National Research Institute for Science Policy (NRISP) no. 1456 for financial support of this work. AM appreciates National Institute for Genetic Eng

• br Acknowledgments This study is a

  2023-04-18

  

  Acknowledgments This study is a part of a MSc thesis and supported by Scientific Research Projects Coordination Unit of Akdeniz University (grant number: 2011.02.0122.007). Introduction Apelin receptor (putative receptor protein related to the angiotensin receptor AT1, APJ) belongs to the G-p

• br The pathogenesis of AD and

  2023-04-18

  

  The pathogenesis of AD and the targets of apelin Alzheimer's drugs Conclusions Introduction APJ, first identified from a human genomic library in 1993, belongs to a member of seven trans-membrane G protein-coupled receptor family. Its amino UM 171 sequence has 31% homology with that of t

• The chronic induction of skeletal muscle AMPK

  2023-04-17

  

  The chronic induction of skeletal muscle AMPK activity is an attractive therapeutic approach for DMD, as it addresses multiple cellular pathways needed for powerful phenotypic plasticity, including activation of the slow oxidative myofiber program, corrective autophagic signaling, as well as regulat

• Since the first studies of betaine aldehyde oxidation in rat

  2023-04-17

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other nm osi receptor as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of att

• The inflammatory cytokine IL is an

  2023-04-17

  

  The inflammatory cytokine IL-6 is an additional factor that has been hypothesized to contribute to epinephrine-mediated repression of drug detoxifying proteins such as CYP3A4 (Aninat et al., 2008). Indeed, this CYP is well-known to be repressed by IL-6 (Dickmann et al., 2011) and epinephrine has pre

• A promising target that is involved in the biosynthesis

  2023-04-17

  

  A promising target that is involved in the biosynthesis of the precursor LTA4 is the 5-LO-activating protein (FLAP), which in vivo is seemingly indispensable for LT formation [8], [9]. FLAP, a member of the MAPEG family (membrane-associated proteins in eicosanoid and glutathione metabolism), is an i

• For both the hydroxylation and lyase

  2023-04-17

  

  For both, the 17α-hydroxylation and 17, 20-lyase reactions, the heme iron center of P450 17A1 receives electron reducing equivalents from CPR. Both reactions require one pair of electrons and molecular oxygen for the conversion of the substrate into product in each catalytic cycle. However, the 17,2

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