• br Experimental section br Introduction NMDA

  2024-07-31

  

  Experimental section Introduction NMDA receptor-induced increases in AMPAR trafficking to the synaptic surface mediates changes in synaptic efficacy in a number of Valrocemide mg regions (Shi et al., 1999, Sun et al., 2005, Frenkel et al., 2006). While this process has been linked to the regul

• Recent studies demonstrated that AHR has an

  2024-07-30

  

  Recent studies demonstrated that AHR has an important role in the interplay between cancer metabolism and tumor-specific immunity. Tryptophan catabolism is increasingly recognized as a metabolic pathway that promotes tumorigenesis through its role in immune suppression [75]. The rate-limiting enzyme

• PCP inhibitor br Experiment br Results and discussion br Con

  2024-07-30

  

  Experiment Results and discussion Conclusion Introduction Tuberculosis (TB) is a chronic specific bacterial infection caused by bacteria of the Mycobacterium tuberculosis [1]. TB remains one of the deadliest diseases in the world. It is the second leading infectious cause of death after

• The acetylcholinesterase AChE inhibitor tacrine THA

  2024-07-30

  

  The acetylcholinesterase (AChE) inhibitor, tacrine (THA), exerts neuroprotective effects in time- and does-dependent manners against glutamate neurotoxicity (Takada-Takatori et al., 2006a, 2006b) and amyloid-β protein toxicity in PC12, a pheochromocytoma line (Wang et al., 2002; Xiao et al., 2000).

• In earlier experiments on snails a behavioral model was

  2024-07-30

  

  In earlier experiments on snails, a behavioral model was employed of certain food rejection to study the mechanisms of the reconsolidation of long-term associative memory. It was found that conditioned food stimuli (reminder) presentation, combined with injections of NMDA glutamate receptor antagoni

• Whereas more research is needed to

  2024-07-30

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the ubiquitin conjugating enzyme that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completel

• br Acknowledgement This work was funded by

  2024-07-30

  

  Acknowledgement This work was funded by NIH/NINDS grant number NS080967 to C. Waites. Introduction Macro-autophagy also called autophagy is a conserved pathway for the lysosomal degradation and recycling of intracellular materials. It is instrumental for the homeostasis of cells and tissues a

• br Results and discussion br Conclusion In summary

  2024-07-30

  

  Results and discussion Conclusion In summary, a series of indazole-based derivatives were synthesized and SAR studies conducted, with view to the development of a novel Aurora kinases inhibitor. The carboxylic AG-14361 group extending from the C-3 position of the aniline and substituted group

• br Results br Discussion The A nidulans Aurora

  2024-07-30

  

  Results Discussion The A. nidulans Aurora kinase displays diverse locations during mitosis and we show here that it also locates to hyphal regions where septa subsequently form, to the septal pore region of newly formed septa and displays a Alisol B 23-acetate specific location to mature sept

• The combination of Aurora kinase

  2024-07-30

  

  The combination of Aurora kinase inhibitors with standard chemotherapeutics or radiotherapeutics are currently in progress, such as AZD1152 plus radiotherapy in various solid cancer models. In addition, Azzariti et al. found that AZD1152-HQPA enhanced oxaliplatin and gemcitabine effectiveness in the

• sn 38 Hypoxia of the adipose tissue is a key

  2024-07-30

  

  Hypoxia of the adipose tissue is a key step in the inflammatory response linked to obesity and contributes to accelerated tumor progression in the obese population (Rosenow et al., 2013). Intermittent hypoxia exposure induces a 2.2-fold increase in the infiltration of tumor-associated macrophages an

• Although the role of apelin

  2024-07-30

  

  Although the role of apelin and APJ receptor in cardiovascular functions has been well-elucidated, little is known for the effect of the central apelinergic system on gastrointestinal (GI) functions. In mice, it has been found previously that central exogenous apelin-13 decreased gastric emptying (G

• br Concluding remarks br Definition Prion diseases are fatal

  2024-07-30

  

  Concluding remarks Definition Prion diseases are fatal neurodegenerative disorders that are caused by an unconventional agent that is neither bacterial nor viral, but is in essence an infectious misfolded amyloidogenic protein, termed a prion (Prusiner, 1982). Once considered highly controvers

• Since at least prospective cohort studies have

  2024-07-29

  

  Since 2005, at least 14 prospective cohort studies have been conducted to clarify inconsistencies in the field, ten of which suggested a direct correlation between antibiotic use and atopy or wheezing later in life [51–60], three found no association [61–63], and one found positive association only

• br Materials and methods br Results

  2024-07-29

  

  Materials and methods Results Discussion We demonstrate reduced angiogenic activity in NDRG1 overexpressing malignant glioma leading to reduced glioma growth. This antiangiogenic phenotype is paralleled by a significant upregulation of the antiangiogenic gene TNFSF15. TNFSF15 upregulation i

15828 records 101/1056 page Previous Next First page 上5页 101102103104105 下5页 Last page