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In mouse lung arsenite enhances the formation
2020-01-19
In mouse lung, arsenite enhances the formation of cigarette smoke-induced 8-oxodeoxyguanine (Hays et al., 2006) and BaP-induced DNA adducts (Evans et al., 2004). Moreover, arsenite inhibits the repair of BaP-induced DNA adducts in human lung carcinoma A549 Sitafloxacin Hydrate (Schwerdtle et al., 2
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br Materials and Methods br Results br Discussion
2020-01-17
Materials and Methods Results Discussion ROS generated by SFN target many signaling pathways involved in initiating cancer cell death (Sestili and Fimognari, 2015). For example, ROS have been shown to activate both intrinsic and extrinsic caspase cascades in prostate cancer cells (Singh et
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As EBI is highly important for generation of
2020-01-17
As EBI2 is highly important for generation of an efficient T cell-dependent humoral immune response [[5], [6], [7]] it may be that aberrant expression or other dysregulation of this receptor contributes in B cell pathologies. In line with this, EBI2 expression is down-regulated in diffuse large B-ce
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There is literature precedence for the metabolic activation
2020-01-17
There is literature precedence for the metabolic activation of the methylene carbons adjacent to the ring oxygen(s) of dioxanes and benzopyrans resulting in ring-opened electrophilic carbonyl species. Based on the potential for this metabolic pathway being operative with , a steric block approach wa
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br Funding sources br Introduction Psychiatric comorbidities
2020-01-17
Funding sources Introduction Psychiatric comorbidities affect up to 70% of people with pharmacoresistant epilepsy and significantly impact quality of life [1]. Psychiatric comorbidities in epilepsy have been thought to be due to psychosocial stress. However, recent evidence suggests a more com
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br Acknowledgments br Casein kinases CK are serine threonine
2020-01-17
Acknowledgments Casein kinases (CK) are serine/threonine-specific enzymes and can be divided two subtypes: casein kinase 1 (CK1) and casein kinase 2 (CK2). CK1 contains at least seven isoforms (α, β, γ1, γ2, γ3, δ and ε) expressed in eukaryotic organisms, CK1 is involved in various cellular pro
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br The modulation of ER
2020-01-17
The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective 2-D08 receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinity, despite lac
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br Materials and methods br
2020-01-17
Materials and methods Results and discussion Conclusions The current research work deals with preparation of CES from RHA and comparative study of Ni (II) ion adsorption on CES and RHA. It was observed that carbon embedded silica shows more porous structure and more surface area as compared
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The mRNA expression of asEP studied by RT PCR
2020-01-17
The mRNA expression of asEP4 studied by RT-PCR shows that EP4 is expressed in many different tissues in Atlantic salmon which is comparable to other species (Sugimoto and Narumiya, 2007) although some distinct differences are present. For example, in mice the expression of EP4 receptor was found to
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Our present results support a major role of EP receptors
2020-01-17
Our present results support a major role of EP1 receptors in peripheral heat sensitization and a smaller contribution to central heat sensitization but no contribution to mechanical sensitization. While the contribution of peripheral EP1 receptors to heat hyperalgesia is in good agreement with the a
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br Introduction Hydrogen sulfide H S and nitric oxide
2020-01-17
Introduction Hydrogen sulfide (H2S) and nitric oxide (NO) are important gasotransmitters in the cardiovascular system and instrumental to the fine control of vascular tone [1] and cellular function [2]. NO is synthesized from l-arginine by calmodulin-dependent endothelial nitric oxide synthase (e
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br Materials and methods br
2020-01-17
Materials and methods Results Discussion Chronic inflammation is central to COPD and plays a critical role in the disease pathogenesis and progression. Among the various inflammatory cells, neutrophils are the key players in COPD pathogenesis. Their numbers are raised in airspaces and lung
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The identification of CCR B cells within the
2020-01-17
The identification of CCR6+ AC220 ic50 within the LZ as direct progenitors of MBCs provides a new window into the evolution of immune responses. In practical terms, flow-cytometric detection of CCR6+ GC B cells could provide a means of rapidly assessing vaccine efficacy when applied to fine needle
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The present study was set
2020-01-17
The present study was set to characterise the DNMT gene orthologs and describe the expression patterns of these genes during seed development in natural diploid apomict B. divaricarpa and diploid sexual B. stricta. Material and methods Results The B. stricta genome v1.2, was sequenced and ass
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Data on optimal hormone formulations routes of administratio
2020-01-16
Data on optimal hormone formulations, routes of administration, doses and duration of hormone use in young women with POF are lacking (Box 1). Transdermal Cyclo(RGDyK) administration, which avoids the first-pass hepatic circulation and the increase in inflammatory markers such as C-reactive protein,
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