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5959 The loss of secondary mutation T M
2020-07-03
The loss of secondary mutation T790M mutation after AR and SCLC transformation was also reported for Rociletinib. Piotrowska et al. using the MGH NGS platform recently reported in 13 biopsies among 12 EGFR T790M+ patients progressing after treatment with Rociletinib the loss of EGFR T790M mutation i
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Expression of MGMT in human cells can be
2020-07-03
Expression of MGMT in human Otamixaban can be switched off by enzymatic methylation of a cytosine residue in the MGMT promoter sequence. In this regard, both MGMT and the mismatch repair function MLH1 belong to a subset of DNA repair genes that are subjected to epigenetic control. In consequence, ab
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The promoter regions of all MdDGKs examined here included
2020-07-03
The promoter regions of all MdDGKs examined here included many hormone-responsive and stress-responsive elements, such as ABRE, MBS, TC-rich repeats, HSE, and LTR. Despite assumptions about how those promoters might control expression in response to environment stimuli, we found several exceptions.
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Sex has been shown to mediate the relationship between
2020-07-03
Sex has been shown to mediate the relationship between allelic differences in COMT and behavior (Harrison & Tunbridge, 2008). The COMT promoter region contains 2 estrogen response elements (Xie, Ho, & Ramsden, 1999) that can inhibit the formation of COMT (Jiang, Xie, Ramsden, & Ho, 2003). With regar
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EPZ-6438 Located on the fore tarsals of the front pair of
2020-07-03
Located on the fore-tarsals of the front pair of legs, the Haller’s organ is presumed central to tick chemosensation. Recent genomic, transcriptomic and proteomic investigations have identified several families of transmembrane proteins in the forelegs of ticks that are likely involved in olfactory
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While previously reported optimizations on
2020-07-03
While previously reported optimizations on R788 disodium focused on the phenyl ring A () and substituents on isoxazole ring, other alternatives to replace isoxazole ring were never explored. Herein, we propose to replace the isoxazole with its bioisosteric substituted phenyl ring B () to explore new
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Because most fusion detection methods were developed to
2020-07-02
Because most fusion detection methods were developed to analyze paired-end reads (and especially Illumina data), they are not suitable for identifying fusion junction-spanning reads in single-end Ion Torrent libraries. Therefore, we developed the FusionDetect algorithm (implemented in the ChildDecod
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In vitro studies suggest that cPLA does not
2020-07-02
In vitro studies suggest that cPLA2α does not show clear preference for the headgroup present at the sn-3 position, although a slight preference for zwitterionic phospholipids such as PC and PE has recently been pointed out [24]. In this regard, mass spectrometry analyses of glycerophospholipid hydr
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Since the dideoxy analogues and served as substrates for TgT
2020-07-02
Since the 1,2-dideoxy analogues, and , served as substrates for TgTCEA and TgTCEB, respectively, with the higher affinity (lower ) and lower turnover number (lower ) than their authentic substrates, PosA and PosB (such trend was more evident on analogue for TgTCEB than on analog for TgTCEA), an intr
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Palliative surgeries for refractory epilepsy include vagus
2020-07-02
Palliative surgeries for refractory epilepsy include vagus nerve stimulation and corpus callosotomy. Among 220 individuals with CDD with parent-entered data, 17% had a vagus nerve stimulation implanted and 69% of parents reported reduced seizure frequency. These data are consistent with a case repor
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br Prostaglandin D PGD is derived from
2020-07-02
Prostaglandin D (PGD) is derived from the metabolism of arachidonic AZD8055 by cyclooxygenases and downstream PGD synthases. In the immune system, PGD is mainly produced by mast cells but also although at lower levels, by macrophages and Th2 lymphocytes. PGD binds to three different receptors, the
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br Role of cysLT signaling on various neurological complicat
2020-07-01
Role of cysLT signaling on various neurological complications which are associated with Alzheimer’s disease Alzheimer’s disease, first described in 1906 by Alois Alzheimer, is a neurodegenerative disease and a very common cause of dementia progressively leading to death. Even though years of rese
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The majority of pro inflammatory cytokines are regulated by
2020-07-01
The majority of pro-inflammatory cytokines are regulated by NFκB, and recently, it has been found that p38 MAPK partly regulates NFκB-driven gene ON-01910 by increasing the association of the basal transcriptional factor, TATA-binding protein, with the C terminus of p65 subunit of NFκB and increasi
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Bryostatin 1 br Discussion The present results demonstrate t
2020-07-01
Discussion The present results demonstrate that high dose estrogen–progestogen OC treatment produced impaired glucose tolerance and glucose tolerance was preserved during low dose estrogen–progestogen, high or low dose progestogen-only OC use. The study also shows that impaired glucose tolerance
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It has previously been shown that human melanocytes are
2020-07-01
It has previously been shown that human melanocytes are responsive to a multiplicity of hormonal triggers [10], particularly to pituitary or ovarian hormones [11]. Studies concerning the effects of MDV 3100 on human melanocytes led to inconsistent data [12], [13]. Im et al. [14] reported that the re
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