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Introduction Human cytomegalovirus CMV is a herpesvirus whic
2020-07-31
Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss
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The aim of this work is to explore
2020-07-30
The aim of this work is to explore different recycling QNZ as fusion partner for two oxidoreductase enzymes (BVMO and ADH), and to compare their strengths and weaknesses for biocatalytic applications. We fused three different regenerating enzymes to a BVMO (TmCHMO, from Thermocrispum municipale) [1
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Three DDR binding sites have been mapped on
2020-07-30
Three DDR2 binding sites have been mapped on the collagen triple helix by us for collagen type 1 and by others using the collagen toolkit for collagen type 2. All of the three reported binding sequences are conserved in the α1 chain of collagen types 1, 2 and 3. The central motif sequence GARGQAGVMG
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br Materials and Methods br
2020-07-30
Materials and Methods Acknowledgements Introduction Collagen fibrillogenesis, the assembly of collagen fibers, is a critical process in the development, maturation, and repair of mammalian tissue. Alterations in the structure and amount of deposited collagen fibers can greatly alter the int
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br Results br Discussion In the present study we
2020-07-30
Results Discussion In the present study, we found significantly increased CSF levels of IL-4, IL-5, IL-9, IL-10, TNF-α, CXCL8/IL-8, and VEGF-A together with significantly higher detection rates of IL-6, GM-CSF, PDGF-BB and IL-1ra in IHP patients compared with OND patients. Among these, IL-4, I
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PTC209 HBr synthesis C cysteine proteases or VPEs which are
2020-07-30
C13 cysteine proteases or VPEs, which are similar to mammalian caspases, are involved in senescence as well as programmed cell death. Very little is currently known about the exact function of specific VPEs. Previous research has shown that they are responsible for the collapse of the vacuole membr
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Corticosteroids and adrenergic receptor agonists have
2020-07-30
Corticosteroids and adrenergic β2 receptor agonists have been clinically used as effective pharmacotherapy for asthma. In this study, asthmatic response in both S-hexyl GSH-non-treated and treated animals was attenuated by single treatment with dexamethasone or salmeterol. Combination treatment with
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Cannabis use is exceedingly common Bahorik et al and overwhe
2020-07-30
Cannabis use is exceedingly common ((Bahorik et al., 2014) 8%) and overwhelming evidence suggests that, especially during adolescence, it represents a major risk factor for psychosis (Gage et al., 2016), associated with earlier onset and more pronounced symptoms (Arseneault et al., 2002, 2004). More
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In the context of our ongoing studies
2020-07-30
In the context of our ongoing studies to define the phytochemical and biological properties of oxyprenylated secondary metabolites of plant and fungal origin, we wish to report herein the investigation on the interaction of some natural and semisynthetic O-alkylcoumarins with promising ChE inhibitor
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A number of studies have been carried out to understand
2020-07-29
A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key Bax inhibitor peptide V5 receptor of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica na
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br Strategies for producing long acting protein therapeutics
2020-07-29
Strategies for producing long-acting protein therapeutics Significant effort has been expended to discover different approaches to extend the half-lives of protein drugs, not least by evading or interfering with their common clearance pathway. Modifications to protein drugs that prolong their hal
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From the results of previous experiments http www
2020-07-29
From the results of previous experiments with the purvalanol B affinity matrix, it is not clear whether the selective capture of parasite CK1 VUF 11207 fumarate is a reflection of their high abundance or rather their affinity for the ligand compared with other kinases present in the lysates. Based
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In the kidney a number of different tissue compartments incl
2020-07-29
In the kidney, a number of different tissue compartments, including blood vessels, glomerulus, tubules and collecting ducts, secrete ET-1. ETA and ETB receptors coexist in the same PLX3397 synthesis that secrete ET-1, but ETA and ETB also reside in juxtaglomerular and mesangial cells [28]. In polyc
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It is of interest to
2020-07-28
It is of interest to consider an explanation for the apparent phosphorylation of hSSB1 in undamaged cells. One such may be that in order to execute a rapid response to replication inhibition, basal S134 phosphorylation could function to keep hSSB1 in a ‘primed’ state prior to stress. Such an arrange
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DGK silence induced by promoter hypermethylation
2020-07-28
DGKγ silence induced by promoter hypermethylation has been reported in colorectal cancer [15]. To address the underlying mechanism contributed to the aberrant DGKγ down-regulation seen in HCC tumor tissues, we first investigated the methylation status of DGKγ gene promoter in HCC tissues and cell li
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