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br E Ubiquitin Ligases Regulate Central
2020-08-03
E3 Ubiquitin Ligases Regulate Central and Peripheral T Cell Tolerance During the random process of somatic recombination, T cell receptors (TCRs; see Glossary) that recognize self-antigens are commonly generated. Notably, meticulously precise filtering mechanisms, termed tolerance, are necessary
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Palladium catalyzed reduction of methylenedioxy acetophenone
2020-08-03
Palladium catalyzed reduction of 3,4-methylenedioxy acetophenone followed by formylation with α,α-dichloromethyl methyl ether resulted in the key intermediate (). Palladium catalyzed reduction of acetophenone was more efficient than the previously reported method using Wolff-Kishner reduction. Reduc
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Besides having a remarkable progestogenic effect an
2020-08-03
Besides having a remarkable progestogenic effect, an additional characteristic of DRSP is its strong antimineralocorticoid effect and antiandrogenic action [11]. DRSP is characterized by an antimineralocorticoid effect that is stronger when compared to progesterone. The decreasing synthesis of proge
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Actually eNOS enzyme is calcium dependent and participates i
2020-08-03
Actually eNOS enzyme is calcium-dependent and participates in the regulation of blood pressure, platelet aggregation, leukocyte adherence, vascular smooth muscle cell mitogenesis and angiogenesis (Cines et al., 1998). As psoriasis involve hyperproliferative responses including excessive epidermal gr
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DG and PA consist of various molecular
2020-08-03
DG and PA consist of various molecular species with different acyl chains at the sn-1 and sn-2 positions, and consequently, mammalian Preladenant australia contain more than 50 structurally distinct DG/PA species. DGK is a component of PI turnover and initiates PI regeneration (Hodgkin et al., 1998
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DDR regulation of cardiac fibrosis The study
2020-08-03
DDR2 regulation of cardiac fibrosis The study by George et al. is notable for several reasons. One important outcome of this study was the demonstration of a relationship between DDR2 and collagen production in cardiac fibroblasts exposed to Ang II. The authors revealed that DDR2 and collagen produ
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br Methods br Results br Discussion
2020-07-31
Methods Results Discussion Extirpation of freshwater biota is the trend for degraded river systems, and second chances for conservation are rare (Matthews and Marsh-Mathews, 2007, Miller et al., 1989, Taylor et al., 2001). Native fish populations of the MDB have undergone major declines, wi
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Compared to E cadherin the
2020-07-31
Compared to E-cadherin, the mechanisms that upregulate N-cadherin expression during cadherin switching are still largely unknown. One potential mechanism might be the indirect effect of the downregulation of E-cadherin, since a decrease of E-cadherin can release p120 catenin to bind to N-cadherin an
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br Materials and methods br Results br Discussion Kaempferia
2020-07-31
Materials and methods Results Discussion Kaempferia parviflora has been long used as a herbal medicine. Methoxyflavones, which are the major components in this plant, can be used as standards for the characterization of Kaempferia parviflora extract. They can be identified and quantified by
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The closed configuration is secured by interactions involvin
2020-07-31
The closed configuration is secured by interactions involving multiple distal MCC elements 48, 51. First, the IR tail from the CDC20M of MCC docks in the vacant TPR groove from the second APC8 molecule in APC/C. Second, the BUBR1 subunit of MCC hijacks the UBE2C-binding surface on the WHB subdomain
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Our experiments show that the N
2020-07-31
Our experiments show that the N-terminal ubiquitination results in an overall slowing down of Ube2Es toward the E3/substrate rather than affecting their chain-building capacity. The fact that Ube2E1wt activity is not restricted toward mono-ubiquitination is also evident from Fig. 4a, where the full-
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br Author contributions SS conceptualized planned
2020-07-31
Author contributions SS conceptualized, planned and performed all the experiments, did the analysis and wrote the manuscript. AB contributed to experimental design. MMP conceptualized the project and wrote the manuscript and provided funding. Introduction Nearly 60 years since it was first
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Hedamycin isolated from Streptomyces griseoruber belongs
2020-07-31
Hedamycin, isolated from Streptomyces griseoruber, belongs to the highly cytotoxic pluramycin class of TC-I 15 (Figure 3(c)). It consists of a planar anthrapyrantrione chromophore attached to two amino sugar rings at one end and a bisepoxide-containing side-chain at the other end (Figure 3(c)). Heda
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GSA 10 synthesis Given the excellent in vitro pharmacology p
2020-07-31
Given the excellent in vitro pharmacology profiles of methyl ester 28 and primary amide 29 efforts were reengaged on neutral analogs of these leads, with a focus on non-amide replacements for the carboxylic GSA 10 synthesis functionality of 1. Acetonitrile 49 was found to have a good balance of DGA
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Introduction Human cytomegalovirus CMV is a herpesvirus whic
2020-07-31
Introduction Human cytomegalovirus (CMV) is a herpesvirus which has a ubiquitous and worldwide distribution, and is the most frequent cause of congenital infection (Kenneson and Cannon, 2007). The prevalence is around 0.5–1% of all live births and is the leading cause of sensorineural hearing loss
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