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The NMT data showed greater Na efflux and
2020-08-04
The NMT data showed greater Na+ efflux and H+ influx in the roots of transgenic plants compared with the WT after salt stress (Fig. 12), which indicated stronger activity of the Na+/H+ antiporter salt overly sensitive 1(SOS1) in the transgenic Arabidopsis (Jian, 2009, Sun et al., 2009). The possible
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Unlike previous studies examining COMT genotyping in
2020-08-04
Unlike previous studies examining COMT genotyping in healthy controls seeking to explain impulsive behaviors, this study sought to examine COMT genotypes in a large sample of individuals with varying levels of gambling behavior to determine whether COMT Retapamulin was associated with differences i
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The parent tibolone molecule does not bind to the ER
2020-08-04
The parent tibolone molecule does not bind to the ER, but estrogenic activity appears after metabolism to the two 3-OH-metabolites by 3α hydroxysteroid dehydrogenase (HSD) and 3β HSD/isomerase in the liver and intestine [17]. Due to the presence of a 3-OH-group in the A-ring of the steroid skeleton
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br Results br Discussion Fetal development
2020-08-04
Results Discussion Fetal development occurs under conditions of low oxygen tension and steady maternal glucose such that physiologic systems including the pancreas are functionally poised in the prenatal state. Postnatally, oxidative metabolism becomes dominant and intermittent feeding exposes
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Zalcitabine br EphB as a therapeutic target in aerodigestive
2020-08-04
EphB4 as a therapeutic target in aerodigestive cancers Pharmacologically targeting EphB4 Biomarker potential Comparatively speaking, very little is known about the potential of EphB4 as a biomarker, especially in upper aerodigestive malignancies. A recent study by Yu et al. [75] who evaluat
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GSK1838705A br Conclusions br Acknowledgment This study was
2020-08-04
Conclusions Acknowledgment This study was funded by Juntendo University Shizuoka Medical Research Center for Disaster and the Commonwealth Fund of Johns Hopkins. Introduction The Discoidin Domain Receptors (DDRs), comprising DDR1 and DDR2, are collagen-binding receptor tyrosine kinases (RT
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Overall these results indicate that there
2020-08-04
Overall, these results indicate that there may be greater individual differences in the basal expression of CYP3A4 that is independent of any exogenous stimuli and that there is an inherent biochemical limit to the degree to which hepatocytes can be induced (i.e., synthesize active CYP450 enzyme). I
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Bufalin Phosphorylation can also negatively affect DUB activ
2020-08-04
Phosphorylation can also negatively affect DUB activity. The DUB OTULIN is recruited to the NF-κB pathway by binding the HOIP PUB domain with its PUB Interacting Motif (PIM) 76, 77, thus connecting the E3 ligase (HOIP in the LUBAC complex) and the DUB for linear ubiquitin chains. Phosphorylation of
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Classically the D R family activates the G s
2020-08-04
Classically, the D1R family activates the Gαs/olf family of G proteins, leading to activation of adenylyl cyclase (AC) and increased cAMP production, whereas the D2R class recruits Gαi/o signaling to inhibit AC and cAMP production (Beaulieu and Gainetdinov, 2011). In striatal spiny projection neuron
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Among the four rDNA loci two
2020-08-04
Among the four rDNA loci, two hybridisation signals were more intense, but all were localized near the nucleoli detectable by the faint DAPI staining also typical of more decondensed heterochromatin, as exemplified in Fig. 2e. The same nucleus also present heterochromatic foci (dense chromatin regio
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Introduction Cysteinyl leukotrienes CysLTs LTC LTD and LTE a
2020-08-03
Introduction Cysteinyl leukotrienes (CysLTs), LTC4, LTD4 and LTE4, are 5-lipoxygenase pathway metabolites of arachidonic (3S,5S)-Atorvastatin sodium salt and deeply involved in bronchial asthma via activation of CysLT1 receptors [1], [2]. Specific CysLT1 receptor antagonists, including pranlukast
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Results obtained with the CRF receptor antagonists provided
2020-08-03
Results obtained with the CRF receptor antagonists provided evidence that physiological release of CRF and CRF-related peptides within the BNST during restraint modulates the tachycardia through activation of local CRF1 receptors while CRF2 receptors mediates the tail skin temperature responses. Mor
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Cerulenin Compared with the two former cases pure hydrocarbo
2020-08-03
Compared with the two former cases (pure hydrocarbons and oil fractions), predicting water solubility in heavy crudes and bitumens is more challenging due to the complexity of their properties and high asphaltene content of these mixtures. In the case of heavy oils/bitumens + water binary mixtures,
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br Author contributions br Funding The
2020-08-03
Author contributions Funding The QuantiFERON sample sets were provided by Qiagen, Hilden, Germany. Conflicts of interest Acknowledgments Background Congenital cytomegalovirus (cCMV) infection is common, with an estimated birth prevalence of 0.2% in US, Canada, Australia, and Western
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br Materials and methods br Results br
2020-08-03
Materials and methods Results Discussion The role of pro-inflammatory pathways linked to the ubiquitin-proteasome system in the pathogenesis of atherosclerosis is an emerging area of investigation. Indeed, studies demonstrate putative roles of proteasomal blockade, protective effects of ubi
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