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Microglia represent approximately of all
2020-08-06
Microglia represent approximately 5–10% of all glia found in the brain. Various proteases have been detected in the conditioned medium from microglial cell cultures including the metalloproteinase for Aβ40 degradation [34], the cysteine protease cathepsin B for neurodegeneration in the central nervo
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Sulbactam mg Very recently an important role of EBI
2020-08-06
Very recently, an important role of EBI2 expression by innate lymphoid cells type 3 (ILC3) for development of inflammation in the gut in a mouse colitis model was demonstrated [13]. It was shown that stromal cells in the gut produce the EBI2 ligand, which leads to migration of colonic ILC3s into cry
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In neurodegenerative disorders neurons are excited by enormo
2020-08-06
In neurodegenerative disorders neurons are excited by enormous ionic flow which induces mitochondrial dysfunction and apoptosis. Glutamate as the main excitatory neurotransmitter, is released excessively in these diseases. Glutamate acts through N-methyl-d-aspartate (NMDA) receptor and α-amino-3-hyd
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A second mode of collagen
2020-08-06
A second mode of collagen regulation reported earlier by our laboratory shows that the ECD of DDR1 or DDR2 when expressed as a soluble protein can modulate fibrillogenesis of collagen type 1 in-vitro.18, 19 In particular, we found that DDR2 ECD delays collagen fibrillogenesis and the collagen fibers
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DAPK is one of the most frequently methylated
2020-08-06
DAPK is one of the most frequently methylated genes in ovarian cancers [21]. Moreover DAPK can be hypermethylated in cancer of the bladder, lung, colorectum, Cathepsin K Activity Fluorometric Assay Kit uteri and in lymphoma or glioma [31], [32], [33]. We have examined 32 late stage ovarian carcinom
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Remarkably the role of Wolbachia during filarial development
2020-08-06
Remarkably, the role of Wolbachia during filarial development, molting and embryogenesis is similar to the roles attributed to these proteases in filarial development (Lustigman et al., 1992, Lustigman et al., 1996, Lustigman et al., 2004, Tort et al., 1999, Guiliano et al., 2004, Ford et al., 2009)
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br Conclusions By comparing the effects of four
2020-08-06
Conclusions By comparing the effects of four intravenous anesthetics, propofol was found to be the most effective at inhibiting PMA-induced NET formation. This inhibition was mediated by two pathways: reduced ERK phosphorylation and HOCl levels (Fig. 6). The two pathways are independent because E
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TREM is found in various
2020-08-05
TREM2 is found in various tissue macrophages, including CNS microglia and monocyte derived dendritic STF-118804 (Paloneva et al., 2002, Colonna and Wang, 2016). We found that both TREM2 and its adaptor protein DAP12 (Peng et al., 2010) are reduced after DDR1 and DDR2 knockdown, suggesting attenuati
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br Materials and methods br Results
2020-08-05
Materials and methods Results Discussion Conflict of interest Introduction Dopamine-β-hydroxylase (DβH) deficiency is a rare autosomal recessive disorder characterized by the congenital absence of DβH, the enzyme converting dopamine to noradrenaline in sympathetic nerve terminals and
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Maintenance of genomic integrity is complex due
2020-08-05
Maintenance of genomic integrity is complex due to the great diversity of damage that can occur in DNA. Deleterious consequences of damage accumulation may be avoided by a variety of DNA repair pathways, each recognizing and repairing specific types of DNA damage. Base excision repair (BER), nucleot
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DNA methylation is a relatively stable but reversible epigen
2020-08-05
DNA methylation is a relatively stable but reversible epigenetic mechanism that can regulate gene expression, and occurs at the three different cytosine sequence contexts (CG, CHG, and CHH, where H is C, A, or T) in plants [15]. Many studies suggest that DNA methylation status of genes influence pla
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br Materials and methods br Results br Discussion Normal pla
2020-08-05
Materials and methods Results Discussion Normal placental development is dependent on hormone synthesis, trophoblast invasion, and remodeling of maternal uterine decidual spiral Caspase Inhibitor Set I [21]. Dysfunction of a placenta can lead to pregnancy-specific diseases such as preeclam
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In the context of E ligase
2020-08-04
In the context of E3 ligase drug discovery, it is critical to identify the appropriate E2/E3 substrate pairing to ensure the development and use of the most physiologically relevant screening assay. There have been many reports of limited E2/E3 activity profiling with a small number of E2 and E3 BH3
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The lack of robust immunocompetent
2020-08-04
The lack of robust immunocompetent animal models permissive for HCV makes it hard to assess if the quantity and quality of vaccine-induced immunity is sufficient to confer protection. Thus, it is difficult to predict to what extent antibody responses induced by current vaccination approaches, includ
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ALDH A isoform expression has http www apexbt com media
2020-08-04
ALDH1A1 isoform expression has also been detected in gliomas, being correlated with histological grade, proliferation, colony formation, and invasiveness [5]. ALDH1A1 expression was elevated in CSCs of human GBM cell lines, coexpressed with other CSC markers Musashi-1 and Sox-2, and it was proportio
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