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br Results br Discussion SDF performs essential roles in cel
2020-08-10
Results Discussion SDF-1 performs essential roles in cell migration and proliferation, acts as neuromodulator; and is also involved in many pathological processes including human immunodeficiency virus infection, metastatic malignancy, and chronic inflammatory disorders (Feng et al., 1996, Li
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There was a measurable worsening but
2020-08-10
There was a measurable worsening, but not a statistically significant change in the baseline and follow-up best ear hearing scores, where the mean worsening change was 11.9 dB (95% CI: −1.11–24.86, p-value = 0.070). However, of the 16 patients, 14 (87.5%) were found to have clinically significant wo
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Chromocarb br Discussion The present study found cholinester
2020-08-10
Discussion The present study found cholinesterase activity in Saccostrea sp. to vary significantly among three tissue types (digestive gland, gills, adductor muscle) and to respond differentially to four toxicants, three of which were non-organophosphates. Furthermore, a comparison of enzyme acti
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In summary A is a potent orally available endothelin recepto
2020-08-10
In summary, A-216546 is a potent, orally available endothelin receptor antagonist with a high selectivity for the endothelin ETA receptor. The potency and bioavailability of A-216546 suggest that it will have important utility for preclinical evaluation of the pathophysiology of the endothelin syste
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Several large scale clinical studies have
2020-08-10
Several large-scale clinical studies have set out with the common goal to further understand the cognitive impact of menopause and hormone therapies taken by women (Gleason et al., 2015, Greendale et al., 2011, Karlamangla et al., 2017, Rapp et al., 2003, Shumaker et al., 2003). Only one human study
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We found all cases to show at
2020-08-10
We found all cases to show at least some IGF-1R expression by immunohistochemistry. This is consistent with its ubiquity at the mRNA or protein level in ES/PNET cell lines or clinical samples as shown by others.12, 14 Evidence that IGF-1R expression is required for EWS-FLI1 transformation of mouse f
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Gedunin Acknowledgments br Introduction Steroidogenesis the
2020-08-10
Acknowledgments Introduction Steroidogenesis, the process of testosterone synthesis, occurs in the adrenal cortex, testis and ovary, and it is controlled by luteinizing hormone (LH), which is synthesized and secreted from the pituitary (Hanukoglu, 1992, Payne and Youngblood, 1995). In the testis
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br Materials and methods br Results discussion br Conclusion
2020-08-10
Materials and methods Results + discussion Conclusions We have demonstrated the systematic optimization of the functional folding of a CF synthesized GPCR. The approach addresses central issues relevant for many membrane proteins such as disulfide bridge formation, proper hydrophobic enviro
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The Kaempferia parviflora extract met the
2020-08-10
The Kaempferia parviflora extract met the criteria for a non-competitive interaction with CYP1A1 based on the decrease of Vmax and unchanged Km. The high Ki value and low IC50, as well as the high Km value was indicative of the weakness of the interaction between the Kaempferia parviflora extract an
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br Experimental Procedures br Author Contributions br
2020-08-10
Experimental Procedures Author Contributions Acknowledgments Introduction The intestinal mucosal barrier surface is constantly exposed to food antigens, beneficial microbes, pathogens, and a multitude of other environmental stimuli (Turner, 2009). Innate lymphoid abt 737 synthesis (ILCs
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DNMT is the dominating enzyme responsible for
2020-08-08
DNMT1is the dominating enzyme responsible for maintenance of the DNA methylation pattern and the primary enzyme responsible for copying methylation patterns following DNA replication (Moore et al., 2013). DNMT1 maintains the mitotic inheritance of the original methylation pattern in a cell lineage d
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Within the Class II receptors the Type
2020-08-08
Within the Class II receptors, the Type I IFN receptor subunit, IFNAR-1, is exceptional in having four tandem FNIII domains, denoted here D1–D4. This structure appears to have arisen as a tandem 2578 of the basic D1/D2 structure; thus, D1 and D3 of IFNAR-1 are more closely related, as are D2 and D4
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Previously a linear rolling circle amplification RCA has
2020-08-07
Previously, a linear rolling circle amplification (RCA) has been employed to create DNA nanochains or DNAzyme chains for DNA [15], miRNA [16], protein [17] detection. In RCA-based assays, target quantification is achieved through the quantification of the RCA products. In order to improve the sensit
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In normolipidemic CD and C
2020-08-07
In normolipidemic CD-1 and C57BL/6 mice, the maximal increase in serum triglycerides was observed two h after corn oil administration with triglycerides returning towards baseline levels within three h. However, in dyslipidemic ob/ob and apoE−/− mice, serum triglycerides were incrementally increased
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To date two members of the EPAC family proteins have
2020-08-06
To date, two members of the EPAC family proteins have been identified, known as EPAC1 (coded by gene, in human) and EPAC2 (coded by gene, in human)., EPAC1 (cAMP-GEF-I) is an about 100kDa molecular weight multi-domain protein that is highly expressed in developing and mature human tissues. The multi
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