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The role of Epac in the regulation of intracellular
2020-10-16
The role of Epac in the regulation of intracellular Ca homeostasis and contractility is still matter of debate. In rat adult cardiomyocytes, acute Epac stimulation decreased the amplitude of Ca transients [6], [9], [10] with either no changes [6] or increments [9] in cell shortening, suggesting an e
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br Introduction Prostaglandin E PGE signals through separate
2020-10-16
Introduction Prostaglandin E2 (PGE2) signals through 4 separate G-protein coupled receptor sub-types (EP1, EP2, EP3 and EP4) to elicit a variety of physiological and pathophysiologic effects. EP2 and EP4 increase cAMP levels in the cell via adenylate cyclase activation, whereas EP3 inhibits cAMP
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Ruxolitinib phosphate synthesis Accordingly we prepared thre
2020-10-16
Accordingly, we prepared three compounds (, , and ) as shown in . Condensation of commercially available Ruxolitinib phosphate synthesis with glycine methyl ester gave amide . A Friedel–Crafts reaction between compound and 4-methyl valeryl chloride in the presence of aluminum chloride mainly pro
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BCTC TgTCEA from petals TgTCEA and TgTCEB from pollen
2020-10-16
TgTCEA from petals (TgTCEA1) and TgTCEB from pollen grains (TgTCEB1) were used throughout the study. The recombinant enzymes were expressed in , and purified as the His-tag-free forms as described previously., Enzyme reactions were performed at 4 mM substrates under the same conditions as described
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br Experimental Procedures Further details and an outline
2020-10-16
Experimental Procedures Further details and an outline of resources used in this work can be found in Supplemental Experimental Procedures. Introduction In response to T cell-dependent (TD) antigen stimulation, antigen-specific Maraviroc receptor migrate to the periphery of B cell follicles
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Here we report that ILC s sensed oxysterols
2020-10-16
Here, we report that ILC3s sensed oxysterols through GPR183, which was highly expressed by LTi-like ILC3s. 7α,25-OHC-synthesizing enzymes were produced by fibroblastic stromal N-Acetylneuraminic acid found in intestinal lymphoid structures, and the GPR183 ligand 7α,25-OHC acted as a chemoattractant
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br Ubiquitin Capture by the
2020-10-16
Ubiquitin Capture by the Mobile APC11 RING Domain Contributes to Processive Substrate Ubiquitylation Although the rules of Ub-mediated proteolysis are only beginning to emerge, the rate and order in which different APC/C substrates are degraded during the palovarotene receptor correlates with pr
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Initially the cause of hypoglycemia was
2020-10-15
Initially, the cause of hypoglycemia was not apparent. There was no detectable lesion in the pancreas on plain computed tomography, and anti-insulin antibody was negative. Eight hours after hospital admission, his son discovered that the patient had accidentally taken glimepiride 3mg/day for 3 days.
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A previous study suggested that DARs and
2020-10-15
A previous study suggested that DARs and octopamine/tyramine receptors (OARs/TARs) have close pharmacological properties (Beggs et al., 2011). Their relationships were also supported by phylogenetic analyses (Balfanz et al., 2005, Hauser et al., 2008, Wu et al., 2014), indicating that some of DAR an
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All DGKs have at least two cysteine rich
2020-10-15
All DGKs have at least two cysteine-rich regions homologous to the C1A and C1B motifs of PKCs [26]. In theory, these domains may bind DAG, perhaps localizing DGKs to where DAG accumulates. However, no DGK C1 domain has so far been conclusively shown to bind DAG. In fact, structural predictions sugge
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Thiomyristoyl Moreover recent structural studies of VEEV nsP
2020-10-15
Moreover, recent structural studies of VEEV nsP2pro in complex with E-64d revealed an important molecular interaction at the interface of two subdomains. In this structure, Asn475 which is in polar contact with carbonyl oxygen of Asp507 of the protease subdomain makes an H-bond with Arg662 of the MT
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br Introduction The endeavor to achieve a
2020-10-14
Introduction The endeavor to achieve a successful use of commercial-off-the-shelf (COTS) electronic devices in space is not new and the reasons are well known [1], [2], [3]. More recently, COTS have been widely employed in the manufacturing of low-cost, small satellites, for scientific and even c
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A comparison between tinnitus and
2020-10-14
A comparison between tinnitus and controls subjects showed increased activity in the left AUD and PHC for the gamma frequency band. The link between gamma band activity in the AUD and tinnitus has been identified using both EEG (van der Loo et al., 2009) and MEG (Weisz et al., 2005, 2007). This is s
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Since protein kinase CK has over
2020-10-14
Since protein kinase CK2 has over 300 known substrates we examined if the inhibitory effects described above could also be detected using another substrate. Therefore, we employed the synthetic peptide RRRADDSDDDDD which is often used in CK2 inhibitory studies. Quite contrary to the phosphorylation
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Significantly elevated levels of DNA
2020-10-14
Significantly elevated levels of DNA damage observed in peripheral blood of tea garden women workers indicate the occupational exposure. The same was observed in cholinesterase activities, which detected lower activity in the exposed group compared to non-exposed. Large volumes of pesticides are use
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