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br Cyclin dependent kinases control more than cell
2020-12-25
Cyclin-dependent kinases control more than cell cycle CDKs’ roles conducting the concert of hydroxychloroquine sulfate receptor was first revealed in the context of the tumor suppressor Rb, phosphorylation of which by CDK4 or CDK6 inactivates it loosing the transcription factor E2F [1], [12], [1
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Alvocidib flavopiridol is a piperidine chromenone
2020-12-25
Alvocidib (flavopiridol) is a piperidine-chromenone derivative (Fig. 6D) that is not FDA approved, but is in clinical trials for breast, endometrial, and several other cancers and hematological malignancies (Table 4) [[100], [101], [102], [103], [104]]. This drug targets CDK9 (IC50 = 3.2 nM) and CDK
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In contrast exposure of CRF
2020-12-25
In contrast, exposure of CRF2(a) receptors to h/rCRF in living cells produced a strikingly weak translocation of βarrestin2 to the membrane. Specifically, we found a markedly lower magnitude and slower rate of βarrestin2 recruitment to CRF2(a) receptors in response to h/rCRF concentrations as high a
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Within the Class II receptors the Type I
2020-12-25
Within the Class II receptors, the Type I IFN receptor subunit, IFNAR-1, is exceptional in having four tandem FNIII domains, denoted here D1–D4. This structure appears to have arisen as a tandem Methoxyresorufin of the basic D1/D2 structure; thus, D1 and D3 of IFNAR-1 are more closely related, as ar
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After repeated intermittent exposure to a psychostimulant an
2020-12-25
After repeated, intermittent exposure to a psychostimulant an augmentation of drug response to motor activity is commonly observed, a phenomenon known as behavioral sensitization (Kalivas and Stewart, 1991, Steketee and Kalivas, 2011). On the other hand, several reports have pointed out that stress
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The following is the supplementary data related
2020-12-24
The following is the supplementary data related to this article. Funding This work was supported by departmental funding to Prof. Mühl. Funding derived from the State of Hessia to the Institute of General Pharmacology and Toxicology at the pharmazentrum frankfurt (Head: Prof. Josef Pfeilschifter
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sphingosine Interestingly Carver Johnson and Kim investigate
2020-12-24
Interestingly, Carver, Johnson, and Kim (2016) investigated a polymorphism in the OPRM1 μ-opioid receptor gene for its role in sensitivity to social contexts. The G allele of this polymorphism was associated with higher levels of sensitivity. The authors found significant interactions, e.g. the nega
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br Conclusions In a former study we
2020-12-24
Conclusions In a former study we compared the modulating potential of halogenated 1H-benzimidazole derivatives towards CK2 catalytic subunits. Now we were interested if similar differences are also obtained using completely different substances. Some of these natural occurring compounds were alre
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Our module is designed to allow in process
2020-12-24
Our module is designed to allow in-process measurement of [C]-tracer molar activity (MA, GBq/μmol at EOB) using a FAK Inhibitor 14 detector with a UV detector at the outlet of the HPLC-portion of the system. In the HPLC chromatogram, peak analysis of the chromatographic data utilized PeakSimple soft
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In BBR was reported to increase LDL receptor LDLR gene
2020-12-24
In 2004, BBR was reported to increase LDL receptor (LDLR) gene expression by stabilizing LDLR mRNA [4]. Following this report, the same groups conducted additional studies predominantly in HepG2 cells, with similar effects being observed [8], [11], [12], [4]. In addition to LDLR-mediated LDL cholest
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br Acknowledgements br Introduction Water and electrolytes c
2020-12-24
Acknowledgements Introduction Water and electrolytes constitute an integral part of all living things, and A 967079 governing their movements play important roles in a wide variety of physiological and/or pathophysiological processes. Given the importance of channel proteins in cancer cell pr
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We have previously reported the characterization
2020-12-24
We have previously reported the characterization of A-127722, a novel, non-peptide endothelin antagonist that displays very high affinity binding (K=69 pM) with a more than 1000-fold greater affinity for human endothelin ETA than ETB receptor. Although A-127722 is >1000-fold more selective for endot
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Similarly to other investigations the
2020-12-24
Similarly to other investigations, the present study found that ZEA in high concentrations decreases viability of both normal (Liu et al., 2018, Zheng et al., 2018a, Zheng et al., 2018b) and cancer gamma-Glu-Cys (Khosrokhavar et al., 2009, Kowalska et al., 2017). The toxic effect of ZEA observed by
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Key molecules in the EP
2020-12-24
Key molecules in the EP1 second messenger signaling cascade that are necessary for potentiation of GluK2/GluK5 were identified. We also identified three GluK5 serines located in a membrane-proximal C-terminal domain that, when mutated to the phosphomimetic aspartate and expressed with GluK2, rendere
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As a support chitosan presents interesting characteristics
2020-12-24
As a support, chitosan presents interesting characteristics that reinforce its great potential for enzyme immobilization [18,19]. Firstly, it is produced from renewable natural sources in addition to being biodegradable and water insoluble [20,21]. Also, the main peculiarity in the chitosan structur
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