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Several recent reviews have appeared
2021-03-12
Several recent reviews have appeared covering different aspects of the sPLA2 family of enzymes, including sPLA2-V, and the interested reader is kindly directed to these for specific details [34,[135], [136], [137]]. It is important to remark here, however, that recent studies on sPLA2-V suggest that
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br Guidance of B cell localization by EBI
2021-03-12
Guidance of B cell localization by EBI2 EBI2 expression and B cell disease Although chemoattractant receptors of the GPR family play essential roles in coordinating the migration of lymphocytes for efficient responses against pathogens, their dysregulation can result in the initiation or progr
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GLP also showed cardioprotective effects i e infarct size
2021-03-12
GLP-1 also showed cardioprotective effects (i.e., infarct size reduction and ejection fraction improvement) in experimental models of myocardial ischemia-reperfusion injury by suppressing caspase-3 activation and preventing apoptosis of cardiomyocytes [[50], [51]]. Of note, such a cardioprotection w
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br Materials and methods br Results Artemis has
2021-03-12
Materials and methods Results Artemis has been reported to possess 5′–3′ exonuclease activity in vitro on ssDNA, as well as DNA-PK-dependent endonuclease activity on single-strand overhang and hairpin DNA structures [11]. However, enzymes within the metallo-β-lactamase family typically contain
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Moreover maintaining the pyrimidine pool is not
2021-03-12
Moreover, maintaining the pyrimidine pool is not the only important role played by DHODHs. In Toxoplasma gondii, for instance, DHODH plays a second essential function [38] possibly coupled to the mitochondrial respiratory activity, where it replenishes ubiquinol levels and prevents reactive oxygen s
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Furthermore the Langerhans cell infiltrate in skin biopsies
2021-03-11
Furthermore, the Langerhans cell infiltrate in skin biopsies from RG7155-treated patients will be analyzed since keratinocyte derived IL-34 was identified as their survival factor (Greter et al., 2012). Microglia, the other macrophage population regulated by neural progenitor and glial cell-derived
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Stable carbon and nitrogen isotope ratios in bone collagen a
2021-03-11
Stable carbon and nitrogen isotope ratios in bone collagen and carbon isotope ratios in bone apatite data were obtained by the means of the techniques described in supplementary data (SD1). For collagen, standard indicators have been used to assess its preservation, such as collagen yield, carbon an
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br Proposed methodology At the outset
2021-03-11
Proposed methodology At the outset, the wind power outputs must be obtained which are to be included in the OPF model. This work utilizes a modified version of the simulation method. Rather than using the simulated wind power values for each hour of the year, the probability of each wind power in
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Social memory is encoded within certain sites
2021-03-11
Social memory is encoded within certain sites, but meaning depends upon an interpretant (such as a tourist) being able to decode the signs. Memorials, such as cemeteries, require some kind of activity by its visitors for their meanings to be activated (Hutchinson, 2009, Winter, 2010). Following Eden
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br Results and discussion The results and subgroup
2021-03-11
Results and discussion The results and subgroup analysis of cholesterol and NCS from the both surveys are listed in Table 2 and shown in Fig. 1, A1 to E2. Common discussion Unlikely to the other NCS assays, a target value for cholesterol could be reported in the present survey. For NCS assays
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Patients and methods This study
2021-03-11
Patients and methods This study was performed at 3 academic centers (Chung-Ang University YongSan Hospital, Soonchunhyang University Hospital, and Chung-Ang University Hospital) in Seoul, Korea, from November 2008 to November 2010. The study protocol was approved by the institutional review boards
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br Discussion We are reporting a cryptic insertion of
2021-03-11
Discussion We are reporting a cryptic insertion of chromosome 22 material (EWS) to the long arm of chromosome 11 (11q24, FLI-1) recognizable by FISH in ornidazole mg exhibiting trisomy 8 as the sole cytogenetic anomaly. In ES and PNET tumors, trisomy 8 is the most common secondary abnormality [6
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ERK and p MAPK signaling pathways play critical role in
2021-03-11
ERK and p38 MAPK signaling pathways play critical role in genesis and metastasis of melanoma (Tang et al., 2018). >50% of melanoma Sodium salicylate (Abildgaard and Guldberg, 2015) show abnormal activity of BRAF-RAS-RAF to activate MEK signal that drives the growth-promoting extracellular signal-reg
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Further modifications on the position of compound led
2021-03-11
Further modifications on the 8-position of compound led to compound 4 (8-pCPT-2′--Me-cAMP, a.k.a. 007, ), which is a potent (half-maximal activation of EPAC1 at 2.2µM) and selective (about 100-fold EPAC/PKA selectivity) EPAC agonist. Since the discovery of compound , it has been widely used as a po
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On the opposite side sPLA X has
2021-03-11
On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer leuprolide acetate synthesis and promotes their survival during nutrient stress. It acts through the prod
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