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A growing number of other post
2021-05-10
A growing number of other post-translational modifications are implicated in regulation of the ubiquitin system, including substrate modification by hydroxylation, glycosylation, acetylation, methylation, modification by poly(ADP-ribose) (PAR), and attachment of ubiquitin-like modifiers. The HIF1-α
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Primases are classified into two
2021-05-10
Primases are classified into two major groups: first, the DnaG primases, found in bacteria and bacteriophages, and second, the archaeoeukaryotic primases. Remarkably, bacterial and archaeoeukaryotic primases have no structural similarity and, presumably, evolved independently (Leipe et al., 1999). T
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br Material and methods br
2021-05-10
Material and methods Results and discussion Conclusions Acknowledgements S. De thanks DST, New Delhi for generous grant of the SERC Fast Track Scheme No. SR/FT/CS-057/2008. R. Kundu thanks the University of Kalyani for financial assistance. We are grateful to Prof. K. Bhattacharyya of IA
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br Acknowledgement br Introduction Human dihydroorotate dehy
2021-05-10
Acknowledgement Introduction Human dihydroorotate dehydrogenase (hDHODH), a flavin-dependent mitochondrial enzyme involved in de novo ENMD-2076 sale biosynthesis, is a validated therapeutic target for the treatment of autoimmune diseases such as rheumatoid arthritis and cancer [1], [2], [3].
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We also determined the uracil content of
2021-05-10
We also determined the uracil content of CJ236 DNA by thin-layer chromatography of in vivo32P- or [6-3H]uracil-labeled CJ236 2′-deoxyribose 5′-monophosphates as well as by LC/MS of deoxyuridine and thymidine 2′-deoxynucleosides (Table 1, Table 2, Table 3). Examination of the 32P data showed that, ba
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br Transparency document br Acknowledgments This work was su
2021-05-10
Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0
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Crystal structures of various CRM complexes have provided in
2021-05-10
Crystal structures of various CRM1 complexes have provided insight into molecular details of the interactions between CRM1 and its interaction partners during the transport cycle. CRM1 cooperatively binds RanGTP and cargo in the nucleus (Paraskeva et al., 1999). In this ternary complex, RanGTP is lo
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MNs can be obtained from iPSCs using signaling molecules suc
2021-05-08
MNs can be obtained from iPSCs, using signaling molecules such as retinoic vasopressin receptor (RA) and Sonic hedgehog (Shh) (Table S1).4, 5, 12, 23, 24, 25, 26, 27, 28, 29 These methods rely on developmental principles and require changing the combinations of signaling molecules at multiple steps,
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Of all ES cases approximately
2021-05-08
Of all ES cases, approximately 26–28% are metastatic diseases at diagnosis with the remainder being localized disease [14]. Instituting a systemic chemotherapy regimen in combination with surgery and/or radiotherapy has significantly increased the survival of patients with localized disease. The 5-y
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As a co factor CIITA lacks the ability to recognize
2021-05-08
As a co-factor, CIITA lacks the ability to recognize and directly bind to specific DNA elements to regulate transcription; instead, it relies on interaction with sequence-specific transcription factors (TFs) to be recruited to the chromatin. Therefore, the observation that CIITA binds to a specific
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Human neutrophil elastase HNE is
2021-05-08
Human neutrophil elastase (HNE) is a serine protease central to the pathology in a wide range of diseases including chronic wounds, cystic fibrosis, and acute respiratory distress syndrome (Owen, 2008). Although neutrophil proteases are necessary for completion of wound healing, HNE is secreted in h
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br Concluding remarks and prospective Cardiac proteinopathy
2021-05-08
Concluding remarks and prospective Cardiac proteinopathy, a more common disease condition and more frequent cause of cardiomyocyte decay than previously thought, is largely neglected and no effective therapy exists yet. Protein quality control and protein degradation via autophagy or the ubiquiti
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br Ubiquitylation of the TGF BMP
2021-05-08
Ubiquitylation of the TGFβ/BMP pathway components Ubiquitylation is a reversible post-translational modification that is essential in many cellular regulatory mechanisms [20], [21]. During the ubiquitylation cascade, ubiquitin is attached to target proteins through the concerted actions of an E1-
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For radiochemotherapy it is well known that mitotic cell
2021-05-08
For radiochemotherapy, it is well known that mitotic cell death and apoptosis present the major cell death modes. More recently, autophagy-dependent cell death has been described to occur upon radiochemotherapy (Daido et al., 2005, Song et al., 2017). This form of regulated cell death depends on com
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br Discussion Our data demonstrate that the bicyclam
2021-05-08
Discussion Our data demonstrate that the bicyclam AMD3100 strongly interacts with CXCR-4, whereas DS and AR177, two other compounds that also interfere with virus entry into the 99 0 (and interfere with virus binding), do not. AMD3100 is a unique compound in that it interferes with the chemokine
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