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ATP dependent DNA ligases in
2021-06-03
ATP-dependent DNA ligases in vertebrates are divided in three families [7]. Family I DNA ligases are responsible for sealing the nicks during DNA replication and in long-patch base excision repair (BER). Family III DNA ligases are involved in short-patch BER. Lastly, family IV DNA ligases are involv
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The first transcription factor TF known to interact with one
2021-06-02
The first transcription factor (TF) known to interact with one of the cis-acting GAREs is GAMYB protein, the expression of which is induced by GA in the aleurone concentration formula of barley (HvGAMYB) (Gubler and Jacobsen, 1992). GAMYB is an important regulator of endosperm functions during seed
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The CRTH inhibitory activities of the synthesized compounds
2021-06-02
The CRTH2 inhibitory activities of the synthesized compounds are listed in , . At first we introduced halogen or other substituents at the 4,4′-position of phenyl rings in the benzhydryl moiety in order to obtain SAR and to improve the metabolic stability at this moiety (–). It is well-known that in
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However recent studies revealed that the function of
2021-06-02
However, recent studies revealed that the function of Crm1 might not only limit to nucleocytoplasmic transport, but also be involved in regulation of centrosome duplication. As the major microtubule organizing centers in animal cells, centrosomes play a significant role in cell cycle, spindle format
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br Materials and methods br Acknowledgements We
2021-06-02
Materials and methods Acknowledgements We thank Drs. Nathan Sherer (University of Wisconsin-Madison) and Bryan Cullen (Duke University) for generous reagent gifts. The following reagent was obtained through the NIH AIDS Reagent Program, Division of AIDS, NIAID, NIH: HIV-2ROD phage from Dr. Ron
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Another important mediator in fear learning is the neuropept
2021-06-02
Another important mediator in fear learning is the neuropeptide corticotropin-releasing factor (CRF). For example, local repeated administration of CRF into the basolateral amygdala potentiates the acquisition of cue-conditioned fear (Bijlsma et al., 2011) and CRF1 receptor antagonists effectively b
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br Materials and methods br Results br Discussion We
2021-06-02
Materials and methods Results Discussion We initially found that ISL, a natural product with a linear scaffold (2-propenone), is able to inhibit CK2 (IC50 = 17.3 μM). Then we have investigated the inhibitory potential of a novel series of compounds with linear scaffolds by combining fragmen
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With regards to what might represent
2021-06-02
With regards to what might represent a typical “baseline” ChE (or AChE) activity in Saccostrea sp., it Ruxolitinib phosphate should be remembered that the observed enzyme responses were obtained in laboratory exposures, over a narrow experimental window (96h), with specimens collected over the cour
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Patients and methods This study was performed at academic
2021-06-02
Patients and methods This study was performed at 3 academic centers (Chung-Ang University YongSan Hospital, Soonchunhyang University Hospital, and Chung-Ang University Hospital) in Seoul, Korea, from November 2008 to November 2010. The study protocol was approved by the institutional review boards
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Several reasons may explain that other studies using
2021-06-02
Several reasons may explain that other studies using PDE-5-Is yielded negative or contradictory results [30], [31], [32]. Lee [30] applied 50mg sildenafil to seven patients with liver cirrhosis. NO and cGMP in the hepatic Voreloxin significantly increased, hepatic and pulmonary resistance decreased
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The N B method has the overall advantage that
2021-06-02
The N&B method has the overall advantage that it is not restricted to certain dyes specific for energy transfer [55], and is also able to detect higher order receptor Lapatinib Ditosylate on the focal point in living cells. Conclusion The N&B method has shown to be a powerful tool to locate and
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Nevertheless because of the preclinical work and
2021-06-02
Nevertheless, because of the preclinical work and the interference with EWS–FLI1 transcriptional activity, we believe that there may be a role for ET-743 in Ewing sarcoma. An analysis of the pharmacokinetic data published in the phase II clinical trial shows that at most the drug spent 5 to 6days ou
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In particular EphB has been one
2021-06-02
In particular, EphB4 has been one of the most studied receptor of the Eph family: inhibition of EphB4 expression using interfering-RNA or antisense oligonucleotides inhibited proliferation, survival and invasion of PC3 prostate cancer Tankyrase Inhibitors 22 in vitro and in vivo. Inhibition of EphB
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Several studies have shown that independently of
2021-06-02
Several studies have shown that, independently of body-weight control, the central actions of leptin improve glycemic control in obese diabetic rat and mouse models [62]. For instance, restoration of OB-Rb expression in OB-Rb-deficient mice, and in particular in POMC neurons, was sufficient to norma
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It is well established that a number
2021-06-02
It is well established that a number of intracellular signaling pathways mediate sensitization of sensory neurons (Gold and Gebhart, 2010, Richardson and Vasko, 2002). This redundancy could be advantageous since it provides diversity in initiating and maintaining hypersensitivity in response to inju
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