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Conformational changes are observed in the LBDs
2021-11-20
Conformational changes are observed in the LBDs after ligand binding, including partial cleft closure for GluN2A and complete cleft closure for GluN1. For GluN2A, additional conformational rearrangements in the protein and ligand may be required before the ligand can be accommodated within lobe 2. F
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br According to WHO estimates
2021-11-20
According to WHO 2014 estimates, diabetes continues to present an increasing health risk to the global population, affecting 422 million individuals worldwide. Type 2 diabetes (T2D), which affects the vast majority (ca. 90%) of the diabetic population, occurs when the body cannot effectively utili
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As mentioned earlier two different isoforms of TFE have
2021-11-19
As mentioned earlier two different isoforms of TFE3 [16] have been reported viz. the full length (TFE3L) and smaller (TFE3S) without exon 1&2. TFE3S lacks an N-terminal acidic activation domain which is present in TFE3L hence is a dominant negative form of TFE3L [51]. This dominant negative feature
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The objective of this study is to
2021-11-19
The objective of this study is to design and synthesize drug-like molecules with agonistic activity on both receptors; PPARγ and FFAR1. These agents would act as insulin sensitizers and insulin secretagogues through their action on PPARγ and FFAR1, respectively. The design of drugs with dual mode of
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The deduced amino acid sequences of all scIPPSs display high
2021-11-19
The deduced amino bts products sequences of all scIPPSs display high similarity, and sequence alignments reveal seven conserved regions [2]. Regions II and VI contain the substrate-binding regions, with two characteristic aspartate-rich motifs (DDx(xx)xD; where x represents any amino acid residue).
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br Introduction Thrombosis is one of the leading causes
2021-11-19
Introduction Thrombosis is one of the leading causes of deaths in the cardiovascular diseases such as myocardial infarction (MI), unstable blue nitro australia and acute coronary syndrome (ACS) in developed countries [1], [2]. It is estimated that venous thromboembolism (VTE) afflicts about 1 mi
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More specific quantitative assays for DiXaIs are based
2021-11-19
More specific quantitative assays for DiXaIs are based on the inhibition of chromogenic or clotting activity of Factor Xa. During drug development, Kubitza developed an endogenous Anti-Factor Xa assay [45], which is very sensitive to Rivaroxaban drug concentration. This assay was based on Factor Xa
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br Results br Discussion The present findings outline a nove
2021-11-19
Results Discussion The present findings outline a novel regulatory mechanism for fasting-induced ketogenesis, which involves histamine release from mast chronic conditions into the hepatic portal system, H1 receptor-mediated stimulation of liver OEA biosynthesis, and recruitment of the nuclea
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br Introduction The airway epithelium
2021-11-19
Introduction The airway epithelium is the first barrier against inhaled insults and the final barrier against internal forces (hydrostatic, inflammatory, and ischemic) that disrupt water and solute movement across the epithelium. This barrier is formed by adhesion of airway and alveolar epithelia
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br Results and discussion br
2021-11-19
Results and discussion Conclusions A series of novel HDAC inhibitors comprising the thioquinazolinone were designed and synthesized. These derivatives were evaluated for their antiproliferative activities against several human cancer cell lines. Then we chose compounds 7a, 4i, 4o, and 4p to fu
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When analyzing HIV AIDS patients in
2021-11-19
When analyzing HIV/AIDS patients in São Paulo, we detected an association between HIV/HTLV-1/2 infection in black/pardo-colored individuals (OR 2.21, 95% CI 1.21–4.03). However, the majority of serum samples were from patients attending specialized services for hepatitis, other than HIV/AIDS or HTLV
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br Materials and methods br Results br
2021-11-19
Materials and methods Results Discussion I have identified an alternative transcript of the integrin αE gene that is abundantly expressed in testis. In humans, this transcript (hAED) includes part of intron 26 and exons 27, 29, 30, and 31 of the conventional αE gene and Northern analysis in
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The Rab to Rab switch on endosomes co occurs
2021-11-19
The Rab5 to Rab7 switch on endosomes co-occurs with the release of the Rab5 GEF Rabex5 from endosomes, which prevents further Rab5 activation [5]. In addition, the Rab5 GAP is recruited to inactivate remaining Rab5 [67]. Recent data suggest that another GAP, TBC1D5, which binds the retromer complex,
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PSI-7977 receptor Earlier we have shown relationship
2021-11-19
Earlier, we have shown relationship between cytotoxicity and receptor degeneration in PSI-7977 receptor having specific neurotransmitter receptors (Siddiqui et al., 2008). In the present study, exposure to 4-HNE reduced expression of DA-D2 receptors in PC12 cells which was found to be concentration
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Decreased ratio of Treg TH is reported to correlate
2021-11-19
Decreased ratio of Treg/TH17 is reported to correlate with MS disease severity [63]. Treg Simeprevir are the major anti-inflammatory subset of T cells which suppress proinflammatory T-cells by producing anti-inflammatory cytokines, such as IL-10 and TGF-β, as well as play a critical role in maintai
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