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The present study was designed to clarify
2021-12-23
The present study was designed to clarify the distribution and the function of the endothelin receptors in the guinea-pig urinary bladder. We found that endothelin-1 produced a clear tonic contraction via both 15 sale subtypes, the endothelin ETA and ETB receptor, and that sarafotoxin S6c also induc
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orexin a In conclusion the present study shows
2021-12-23
In conclusion, the present study shows that the endothelin system is of importance in the cardiopulmonary vascular pathophysiology of porcine endotoxin shock. In this model, combination of a selective endothelin ETA and a selective endothelin ETB receptor antagonist markedly improved pulmonary circu
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In our previous study we designed and synthesized compounds
2021-12-23
In our previous study, we designed and synthesized compounds of A series from the starting material 4-hydroxy-3-methoxycinnamic WIN 64338 hydrochloride (ferulic acid). These compounds with R group being amino acid residues, fatty acyl group and sulfuryl group showed moderate HDAC inhibition and in v
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Several compounds have been described in the literature as i
2021-12-23
Several compounds have been described in the literature as inhibitors of the sGC. Among them, methylene blue and LY83583 () are not direct sGC inhibitors, but rather block cGMP formation by generating superoxide anion radicals that deactivate NO. Despite their extensive use in plethora of research s
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Urinary hydroxypyrene OHP is a widely used biological marker
2021-12-23
Urinary 1-hydroxypyrene (1-OHP) is a widely used biological marker of exposure to PAHs and indicator for internal dose of activated PAHs (Jongeneelen, 1987, Adonis et al., 2003). PAH metabolites may be excreted either as free or as conjugated compounds. When 1-OHP is measured after treating the urin
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The physiological and pharmacological roles of GPR remain la
2021-12-23
The physiological and pharmacological roles of GPR81 remain largely unclear because of several reasons. The low potency of lactate agonizing GPR81 in the millimolar range, together with its fast metabolic turnover, renders as a challenge in in vivo studies using lactate. Furthermore, there are no po
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Since KYNA concentrations are increased by
2021-12-23
Since KYNA concentrations are increased by aerobic exercise training, we have investigated if it plays a role in peripheral tissue metabolism. Here we show that KYNA regulates adipose tissue energy homeostasis through activation of Gpr35. Activation of this network stimulates the expression of lipid
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The global spread and ever increasing incidence of metabolic
2021-12-23
The global spread and ever-increasing incidence of metabolic syndrome over the past few decades has not only categorized it as an ‘epidemic’ but has also dramatically increased the risk of cardiovascular diseases and diabetes. The increase in prevalence of diabetes in the United States alone has bee
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The Berlin patient is a unique
2021-12-23
The Berlin patient is a unique case and dependent on the histocompatibility-matched CCR5Δ32/Δ32 homozygous donors. These donors occur at a little higher rate in the European Caucasian population, but they are very rare in Asians and Africans.15, 16, 17 The recently developed genome-editing technolog
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DLPC br Experimental section br Introduction Fasting
2021-12-23
Experimental section Introduction Fasting hyperglycaemia in all forms of diabetes mellitus occurs primarily as a result of upsurge in hepatic glucose synthesis (HGS) [1], [2]. Two specific enzymes, glucokinase (GK) and glucose-6 phosphatase (Glu-6-Pase) play crucial role in hepatic glucose pro
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Calcein AM Immunohistochemistry analysis shown ghrelin and G
2021-12-23
Immunohistochemistry analysis shown ghrelin and GHSR-1a immunostaining was located in the epithelial cells of Calcein AM and ducts throughout the lactation, strong immunoreactive cells were detected in L30, L60 and L120 stage. The distribution of ghrelin has been shown in many tissues, including ma
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No G C pattern managed to capture all GQ
2021-12-23
No G4C pattern managed to capture all GQ forming sequences of the reference dataset. The sequences that were missed by even the most flexible models were AGATGGAGTGGAGAGG, AGGAGATGCAGGAG, AGAGGGTAGATGG and TTTTTAAAAGAAGGGGAGGAATAGGGGATATGA. In fact, the former three are not expected to form any unim
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PD128907 HCl The NGS of six Southern Brazil patients reveale
2021-12-22
The NGS of six Southern Brazil patients revealed three different variants: c.472C > T (p.Arg158Trp); c.958G>A (p.Gly320Arg) and c.986T>C (p.Leu329Pro) (Table 2). The amino acids involved in these substitutions were evolutionarily conserved in different species (Fig. 1B). The amino PD128907 HCl invol
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In this paper we demonstrate a diatomaceous earth based
2021-12-22
In this paper, we demonstrate a Boc-MLF based TLC-SERS sensing technique combined with machine learning analysis to quantitatively detect seafood allergen in real spoiled tuna samples. We fabricate a diatomaceous earth TLC plate as a separable SERS-active substrate to detect histamine in artificiall
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In summary P P macrocyclization proved to
2021-12-22
In summary, P2-P4 macrocyclization proved to be an effective strategy to drive activity in this series of HCV NS3 protease inhibitors while microsomal stability was enhanced by the introduction of steric bulk along the tether. This modification augmented the previously-described tactic of improving
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