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Since its development the HCV replicon
2022-03-26
Since its development, the HCV replicon system (Lohmann et al., 1999) has been a critical tool in the HCV antiviral discovery process (Gottwein et al., 2009, Imhof and Simmonds, 2010, Lohmann et al., 1999, Pietschmann et al., 2001, Imhof and Simmonds, 2010, Gottwein et al., 2009). The replicon assay
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Significan http www apexbt com
2022-03-26
Significant DNA damage was observed in hemolymph of molluscs exposed to raw composite tannery effluent as evident from comet assay images. DNA damage was evaluated by the presence of tail resembling that of comet in single strand DNA. Break in DNA strand was reported in the liver and gill Palomid 52
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Of special interest is that
2022-03-26
Of special interest is that riociguat and NO donors decreased the phosphorylation of many proteins in human platelets. This aspect is presently under further investigation but a few comments can be made already here. Of the extensive spectrum and diversity of human protein kinases and protein phosph
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This variant has also been related to a better
2022-03-26
This variant has also been related to a better treatment response in patients with metastatic colorectal cancer subjected to irinotecan-based chemotherapy (Kweekel et al., 2008). Inheritance of this metabolic variability has also been stated to influence better treatment outcomes in breast cancer pa
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br Significant efforts are currently focused on non dopamine
2022-03-25
Significant efforts are currently focused on non-dopaminergic strategies to address the unmet medical needs in schizophrenia, and targeting -methyl--aspartate (NMDA) AH 6809 hypofunction has garnered a great deal of attention., , Elevation of synaptic glycine levels near NMDA-containing synapses,
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br Materials and methods br Results br Discussion
2022-03-25
Materials and methods Results Discussion l-glutamate is the major excitatory neurotransmitter in the brain, and is functionally involved in many processes of the nervous system which have been connected with several neurological diseases [4]. These conditions are characterized by the time-d
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High energy adjusted free glutamate intake among adults
2022-03-25
High energy-adjusted free glutamate intake among adults with high education level (above college) or high poverty income ratio (≥3.50) might be a consequence of the difference in intake of some foods such as vegetables and fruits, reflecting upon their socioeconomic status. Previous studies have sho
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High energy adjusted free glutamate intake among adults
2022-03-25
High energy-adjusted free glutamate intake among adults with high education level (above college) or high poverty income ratio (≥3.50) might be a consequence of the difference in intake of some foods such as vegetables and fruits, reflecting upon their socioeconomic status. Previous studies have sho
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In this study for the first time the electrochemical
2022-03-25
In this study, for the first time: 1) the electrochemical glutamate oxidase-based biosensor was optimized for the determination of low micromolar glutamate concentrations; 2) the algorithm of the analysis of exocytotic and transporter–mediated glutamate release was developed; 3) the comparative anal
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br Methods br Results and discussion Protein analysis of com
2022-03-25
Methods Results and discussion Protein analysis of commonly used cell lines (C6, D54-MG, U87, U251 and STTG1) reveals high KN-92 sale of SXC (Cho and Bannai, 1990, Ye et al., 1999, de Groot et al., 2005, Lyons et al., 2007, Savaskan et al., 2008). Since protein expression can be altered over
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The development of immobilization techniques for glucosidase
2022-03-25
The development of immobilization techniques for β-glucosidase offers a potential way to enable its reuse several times [13]. The aim of immobilization is to trap the enzyme within or on the surface of an insoluble material with retention of its catalytic activity [14]. The immobilization strategy a
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The development of immobilization techniques for glucosidase
2022-03-25
The development of immobilization techniques for β-glucosidase offers a potential way to enable its reuse several times [13]. The aim of immobilization is to trap the enzyme within or on the surface of an insoluble material with retention of its catalytic activity [14]. The immobilization strategy a
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We report on four affected
2022-03-25
We report on four affected children from two unrelated consanguineous IOX4 with moderate to severe ID associated with epilepsy and variable neuropsychiatric features. Using whole-exome sequencing, we identified homozygous missense variants in SLC45A1 (OMIM: 605763), which codes for a neuronal gluco
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It was previously proposed that glucagon acts in the liver
2022-03-25
It was previously proposed that glucagon acts in the liver, in which a signal is produced and relayed to the MJ33 lithium salt via vagal nerves [8], [36], [37]. The concept that the liver is the primary target site was supported by the studies reporting that the glucagon receptor is localized in the
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Ghrelin readily crosses the blood brain barrier Banks et al
2022-03-25
Ghrelin readily crosses the blood Phosphatase Inhibitor Cocktail 1 (100X in DMSO) synthesis barrier (Banks et al., 2002, Banks et al., 2008), and recent studies have identified central nervous system sites of action for ghrelin-mediated appetite and hyperphagia (Alvarez-Crespo et al., 2012, King et
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