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5ht receptors br Materials and methods Unless stated otherwi
2022-05-09
Materials and methods Unless stated otherwise, all chemicals were from Sigma-Aldrich and were of the cell culture grade. HL-1 cardiomyocytes were presented by Dr. W.C. Claycomb (Louisiana State University Health Science Center, New Orleans, LA, USA) [8]. Results and discussion Acknowledgeme
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In the present study VTE recurrence
2022-05-09
In the present study, VTE recurrence occurred in a non-cancer patient during edoxaban administration, representing recurrence rates of 1.7% in non-cancer patients and 0.8% in all patients. In a sub-analysis of cancer patients [27] and the main analysis [19] in the HOKUSAI-VTE trial, recurrent VTE oc
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br Materials and methods br Results
2022-05-09
Materials and methods Results Discussion In general, we have demonstrated that the CRISPR/dCas9-based system, fused with 2 × PP7 and PCP-EZH2, could stably and precisely methylate the H3K27 at specific locus of C/ebpα to silence gene expression and inhibit adipogenic differentiation in 3T3
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While the dogma of the mainstream considers Hippo
2022-05-09
While the dogma of the mainstream considers Hippo pathway as a series of size-controlling kinases, there were still some controversial data supporting that YAP, a vital oncoprotein of Hippo downstream, is antagonistic to regenerative proliferation [[20], [21], [22]]. Known for its expansion-driving
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The HIF complex was initially identified as an important com
2022-05-09
The HIF complex was initially identified as an important component of the cell machinery involved in the response and Phosphatase Inhibitor Cocktail 1 (100X in DMSO) australia to hypoxia (Semenza, 2001). Further studies have shown that HIF can also modulate whole-body energy homeostasis by controlli
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Introduction Hedgehog HH signaling regulates
2022-05-09
Introduction Hedgehog (HH) signaling regulates development, cell proliferation, and tissue repair [1], [2], [3]. In mammals, HH signaling is activated by 3 ligands: Sonic hedgehog (SHH), Indian hedgehog (IHH), or Desert hedgehog; SHH is the most widely expressed in adult tissues [3]. The primary re
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There is increased awareness of HBV reactivation in
2022-05-09
There is increased awareness of HBV reactivation in chronic HCV/HBV co-infected patients treated with DAAs [1], [2]. The recent emergence of this adverse event of DAA therapy is due to the exclusion of HBV co-infected subjects from registration clinical trials evaluating the safety of these treatmen
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To identify structurally novel autophagy inhibitors
2022-05-09
To identify structurally novel autophagy inhibitors, a medium throughput screen of our in-house library of approximately 160,000 compounds was performed. In the screening assay, MCF7 AY 9944 dihydrochloride stably transfected with eGFP-tagged light chain 3 (LC3), were employed, which can be detected
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The neotropical fish Prochilodus lineatus has been widely us
2022-05-09
The neotropical fish Prochilodus lineatus has been widely used in experimental designs for being sensitive to variations in water quality and tolerant to laboratory conditions (Camargo and Martinez, 2006, Cazenave et al., 2014, da Silva and Martinez, 2014, Vieira et al., 2016). Concern and reports a
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The relaxant response to carperitide was influenced
2022-05-09
The relaxant response to carperitide was influenced neither by the removal of the endothelium nor by treatment with the nitric oxide synthase inhibitor or nitric oxide scavenger. This result was to be expected as previous studies showing that the vasodilator action of atrial natriuretic peptide is e
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Over the last years numerous studies gave insights into
2022-05-09
Over the last 15 years, numerous studies gave insights into sGC activation and binding of activators: Photoaffinity labelling studies with cinaciguat suggested the N-terminus of the β1 subunit as target region for this new drug [17]. Schmidt et al. identified the amino acids tyrosine 135, serine 137
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We have shown previously that activation of the TGF
2022-05-09
We have shown previously that activation of the TGFβ/Smad signaling pathway in keratinocytes regulates WM-8014 cytoskeleton organization via non-genomic and genomic mechanisms and that RhoB gene is a target of Smad proteins [12,13]. Although the role of RhoB in early non-genomic TGFβ-induced cell r
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We also investigated fat depots in mesenteric and retroperit
2022-05-07
We also investigated fat depots in mesenteric and retroperitoneal adipose tissues as well as in the liver and verified a reduction in lipid droplets following exercise or exercise and FS oil treatments in the liver from obese mice. Potential molecular candidates in the modulation of adipose tissue b
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Selection of the month br Fibrosis br
2022-05-07
Selection of the month Fibrosis Liver protection device Non-alcoholic steatohepatitis Genetic metabolic liver disease Hepatitis C virus (HCV) infection Hepatitis B virus (HBV) infection Cirrhosis Regeneration Introduction Upon catalysis by hepatic and bacterial enzymes, c
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Like other RNA viruses HCV also
2022-05-07
Like other RNA viruses HCV also exhibits a high degree of genetic diversity, creating a major challenge for the development of both HCV vaccines and pan-genotypic therapeutics (Timm and Roggendorf, 2007). The virus has a total of seven genotypes, with >50 subtypes and millions of quasispecies (Cuype
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