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The first suggestion that histamine may play a role in
2022-07-28
The first suggestion that histamine may play a role in memory consolidation was from Almeida and Izquierdo (de Almeida & Izquierdo, 1986) who showed that the immediate posttraining intracerebroventricular (i.c.v.) administration of 1–10ng of the drug were found to enhance the retention of one-trial
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Hippo Signaling in Cancer Immunity The Hippo pathway has evo
2022-07-28
Hippo Signaling in Cancer Immunity The Hippo pathway has evolutionarily conserved roles in limiting the size of organs [1]. It is a kinase cascade regulating transcriptional complexes in response to various upstream signals (Box 1). At the cellular level, the Hippo pathway inhibits cell proliferati
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In autoimmune diseases lymphocytes penetrate into the inflam
2022-07-28
In autoimmune diseases, lymphocytes penetrate into the inflammatory lesions of tissues, where it is prominently hypoxic or even anoxic, and utilize glycolysis for an energy supply after activation or under hypoxia (Sitkovsky and Lukashev, 2005; Palazon et al., 2014), which is modulated by the oxygen
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The therapeutic potential of acetate has
2022-07-28
The therapeutic potential of acetate has been advocated by research on neurodegenerative disorders such as Canavan's disease (Arun et al., 2010, Mathew et al., 2005), where oral acetate improved motor function in a genetic model of the disorder, and in studies of behavioural phenotypes associated wi
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Etoposide VP a semisynthetic podophyllotoxin derivative
2022-07-27
Etoposide (VP-16), a semisynthetic podophyllotoxin derivative agent, is widely used as a chemotherapic treatment for many cancers (Hande, 1998). VP-16 has been known that its activity is mediated by the interaction with topoisomerase II (an ATP-dependent nuclear enzyme) which regulates DNA topology
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trifluoperazine br Acknowledgments This work was supported b
2022-07-27
Acknowledgments This work was supported by the National Institutes of Health (R01 A1084898) to M.V. Williams and M.E. Ariza. Introduction Female pattern hair loss (FPHL) has emerged as the preferred term for androgenetic alopecia (AGA) in women due to the uncertain relationship between androg
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It is becoming increasingly apparent
2022-07-27
It is becoming increasingly apparent that membrane lipids play a critical role in modulating and regulating protein function. For example, embedding the homologous SLC1 transporter GltPh in a POPE bilayer allowed a third Na+ binding site to be identified from MD simulations [42], and the binding ene
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XL 184 synthesis To confirm that these were bona fide
2022-07-27
To confirm that these were bona fide interactions, we investigated whether the potassium channel subunits or Tmem263 formed complexes with GLT-1 or DAT after immunoprecipitation. Lysates of HEK-293 cells previously cotransfected with HA-GLT-1 or HA-DAT, and either YFP-Kv7.3, YFP-Kv7.2 or YFP-Kv7.5 w
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There are two ways to transport FFAs into cells First
2022-07-27
There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty TAI-1 transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is responsible for u
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Most excitingly we found the increased cells hold
2022-07-27
Most excitingly, we found the increased δ-cells hold the ability to trans-differentiate into β-cells in T1D mice. It has been shown that after near-total β-cell loss, juvenile mice display δ-to-β-cell conversion to recover diabetes, involving de-differentiation, proliferation and re-expression of is
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In this study we demonstrate
2022-07-27
In this study, we demonstrate that the ETS transcription factor ETV5 is involved in the regulation of ghrelin system in response to the altered nutritional state. In the recent multiple GWAS studies, three single nucleotide polymorphisms (SNPs) of ETV5, rs7647305 (Thorleifsson et al., 2009; Willer e
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br Acknowledgements We thank the following individuals
2022-07-27
Acknowledgements We thank the following individuals for notable contributions to this work: Dr. Ruth Wood, Dr. Alan Watts, Dr. Casey Donovan, Andrea Suarez, Emily Nakamoto, Allison Apfel, April Banayan, and Jonathan Cheung. This study was supported by the National Institute of Health grants, DK10
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Sickle erythrocytes are known to have an
2022-07-27
Sickle erythrocytes are known to have an increased adhesion to endothelial ARRY-380 (Hebbel et al., 1980, Hebbel et al., 1981a, Hebbel et al., 1981b, Wautier et al., 1985, Mohandas and Evans, 1987). Understanding the events associated with vaso-occlusion requires a detailed knowledge of the interac
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Cx mimetic peptides short synthetic peptides corresponding t
2022-07-27
Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino 3,4-DAA sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in a concentra
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br Short Communication Lactococcus lactis is traditionally u
2022-07-27
Short Communication Lactococcus lactis is traditionally used as a starter culture in the production of fermented dairy food products, such as cheese, sour cream, and buttermilk (Cavanagh et al., 2015). Two main pathways of lactose uptake and metabolism have been described for L. lactis. In the fi
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