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In an effort to determine if
2022-10-26
In an effort to determine if one 5ARI was more effective than the other, the Enlarged Prostate International Comparator Study (EPICS) [17] compared treatment with finasteride and dutasteride in 1630 men over the age of 50 and concluded that after one year of treatment, both groups had statistically
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Five alternatively spliced isoforms of ATX
2022-10-26
Five alternatively-spliced isoforms of ATX have been described and all are catalytically active [16], [17]. The original ATX described in 1992 is termed ATXα, whereas the most abundant isoform is ATXβ and is the same isoform responsible for plasma lysoPLD activity [18]. Full length ATX is synthesize
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NOXA a BH only protein is best known
2022-10-26
NOXA, a BH3-only protein, is best known as a selective inhibitor of MCL-1, which is a highly expressed pro-survival protein in many human malignancies [30]. In addition, NOXA was recently proven to act as a direct activator via directly binding to BAX to induce apoptosis [31]. Given that its levels
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DRiPs also contribute to formation of protein aggregates
2022-10-26
DRiPs also contribute to formation of protein lpl receptor that result from dysregulation of proteostasis, during which the proteolytic machinery is unable to process and degrade defective proteins (Tyedmers et al., 2010). Aggregation of poly-ubiquitinated proteins has been observed in different ce
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br Conflicts of interest br Introduction Phosphatidic
2022-10-26
Conflicts of interest Introduction Phosphatidic glucose transport proteins phosphatase (PAP) enzymes are responsible for catalyzing the reaction that dephosphorylates phosphatidic acid (PA), which in turn produces diacylglycerol (DAG) and a phosphate group during phospholipid regulation (Fig.
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br Introduction Lipoxygenases LOXs are a
2022-10-26
Introduction Lipoxygenases (LOXs) are a heterogeneous family of enzymes that catalyze the peroxidation of polyunsaturated fatty acids (PUFAs). By oxidizing free PUFAs, they were shown to contribute to the generation of various bioactive lipid mediators. However, LOX-mediated oxidation of PUFAs es
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Regulators of the DDR have therefore become attractive targe
2022-10-26
Regulators of the DDR have therefore become attractive targets for cancer therapy primarily through two potential approaches. First, to be used as chemo- or radiosensitisers to increase the effectiveness of standard genotoxic treatments and to help prevent or overcome the development of resistance.
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Unfortunately results of serum plasma
2022-10-26
Unfortunately, results of serum/plasma AC assessment after food antioxidant intake are rather controversial: although some papers reported an increase of AC after food antioxidant intake (Khan et al., 2015, Torabian et al., 2009), unexpectedly, in a lot of long-term intervention studies (days, weeks
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BIIB021 receptor br Introduction Humans have consumed mushro
2022-10-26
Introduction Humans have consumed mushrooms for centuries because of their high nutrient content and low lipid content, as well as their excellent flavor and texture [1]. Edible mushrooms possess notable medicinal properties and bioactivities, including antitumor, antiviral, antidiabetic, and ant
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Given that neither case is derived from
2022-10-26
Given that neither case is derived from multiplex Dehydroandrographolide with affected individuals, principles of Mendelian segregation cannot be applied to implicate the T201S mutation in causing familial CJD. In addition, like many rare gene variants, it is not possible to apply practice guideline
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br AR mediated actions in cells
2022-10-26
AR-mediated actions in nox4 of the vascular wall Sex hormones may influence the size and composition of atherosclerotic lesions indirectly by modifying systemic cardiovascular risk factors such as plasma lipids profiles and insulin sensitivity; this aspect of their action is discussed elsewhere (
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The AMP Activated Protein Kinase AMPK
2022-10-26
The 5′AMP-Activated Protein Kinase (AMPK) has evolved as an important cellular sensor of reduced energy status that can subsequently phosphorylate its target proteins, slowing the rates of key biosynthetic processes and promoting energy producing pathways; for these reasons AMPK has been proposed as
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Volatile esters are important to wine
2022-10-25
Volatile esters are important to wine quality and to fresh berry grape flavor, especially in fox grapes (V. labrusca) [16]. Volatile esters such as Z-3-hexyl acetate can be found in V. vinifera ‘Cabernet Sauvignon’ berries albeit at low levels and their accumulation diminishes to below detection lev
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br Serine glycine and one carbon metabolism Altered
2022-10-25
Serine/glycine and one-carbon metabolism Altered serine metabolism in tumors was noted nearly half a century ago, and elevated flux through the de novo serine synthesis pathway (SSP) is a common phenomenon in cancer luciferin definition [43]. The SSP branches from glycolysis at the point of 3-ph
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br Conclusion br Conflict of Interest br Author Contribution
2022-10-25
Conclusion Conflict of Interest Author Contributions Acknowledgements This work was supported by a research grant (SR/50/AS-14/2012) from the Department of Science and Technology, New Delhi, India to CMC and CSIR Senior Research Fellowship (09/013(0339)/2010-EMR-I) to SB. Introduction
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