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Our previous study revealed expression of AhR in
2023-06-20
Our previous study revealed expression of AhR in human parotid gland in cytoplasm of striated duct HBC (Drozdzik, Kowalczyk, Urasińska, & Kurzawski, 2013). In a further study we observed regulation of AhR expression and function by its specific inducer, i.e. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD
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Our previous study revealed expression of AhR in
2023-06-20
Our previous study revealed expression of AhR in human parotid gland in cytoplasm of striated duct HBC (Drozdzik, Kowalczyk, Urasińska, & Kurzawski, 2013). In a further study we observed regulation of AhR expression and function by its specific inducer, i.e. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD
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br Effective therapeutic window of
2023-06-17
Effective therapeutic window of AR actions on ROP Retinal vasculature undergoes critical developmental changes postnatally: from P7 onward the superficial Lonafarnib start sprouting vertically in retina to form first the deep then the intermediated vascular plexus in the retina of C57BL/6 mice (
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G actin has a molecular
2023-06-16
G-actin has a molecular weight of 42 kD and dimensions about 55 × 55 × 35 Å3. It consists of 375 amino acids arranged into two individual domains (Alberts et al., 2014). A central cleft bisects the protein into two aforementioned domains which surround a deep cleft containing ATP or ADP and a tightl
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Physiology genetics and biochemistry of CYP A br Clinical
2023-06-13
Physiology, genetics, and TC-I 2000 mg of CYP17A1 Clinical presentation and diagnosis Treatment Acknowledgements I thank Dr. Hwei-Ming Peng for assistance with preparing Fig. 3. This work was supported by grant R01GM086596 from the National Institutes of Health. Introduction Prostate c
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Aurora kinases are a conserved
2023-06-13
Aurora kinases are a conserved family of serine/threonine kinases that are important for the transition through mitosis and amplification and overexpression of Aurora kinases have been implicated in filgotinib and transformation. Aurora B is located at the centromere and controls aspects of kinetoc
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Cerebral ischemia occurs following the occlusion of
2023-06-12
Cerebral ischemia occurs following the occlusion of a cerebral artery by a thrombus and causes cell swelling due to cytotoxic edema and BBB disruption with vasogenic edema (Loreto and Reggio, 2010, Nakaji et al., 2006, Shibata et al., 2004). Vasogenic edema is directly linked to alteration of the BB
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To clarify the molecular mechanism of maduramicin
2023-06-09
To clarify the molecular mechanism of maduramicin-induced apoptosis in chicken myocardial cells, the mRNA levels of bcl-2, bax, and cytochrome C, as well as the mRNA levels and activities of caspase-3/8/9 were determined. The mRNA expressions and activities of initiator casapase-9 and executioner ca
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To clarify the molecular mechanism of maduramicin
2023-06-09
To clarify the molecular mechanism of maduramicin-induced apoptosis in chicken myocardial cells, the mRNA levels of bcl-2, bax, and cytochrome C, as well as the mRNA levels and activities of caspase-3/8/9 were determined. The mRNA expressions and activities of initiator casapase-9 and executioner ca
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There is a delicate balance between ROS
2023-06-09
There is a delicate balance between ROS generation and scavenging by the protective antioxidant defenses in the cell. Antioxidant systems present in the ceritinib australia include enzymes like superoxide dismutase (SOD), catalases, glutathione peroxidases (GPxs) and peroxiredoxins (PRxs) (Fig. 3)
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There is a delicate balance between ROS
2023-06-09
There is a delicate balance between ROS generation and scavenging by the protective antioxidant defenses in the cell. Antioxidant systems present in the ceritinib australia include enzymes like superoxide dismutase (SOD), catalases, glutathione peroxidases (GPxs) and peroxiredoxins (PRxs) (Fig. 3)
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The specific mechanisms underlying glutamine dependency
2023-06-05
The specific mechanisms underlying glutamine dependency are still being explored, and current research indicates that the mechanisms likely vary between breast cancer subtypes. In HER2-positive breast cancer, increased levels of the transcriptional activator PGC-1α lead to expression of genes that m
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Numerous studies have reported high glutamate
2023-05-30
Numerous studies have reported high glutamate levels in the brains of patients with depression, indicating that the glutamate system plays a crucial role in depression (Sanacora et al., 2004; Kendell et al., 2005; Hashimoto et al., 2007). Furthermore, several clinically effective antidepressant drug
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The c C T mutation identified in subject K was
2023-05-30
The c.286C>T mutation identified in subject K20-1 was also reported in other ethnic groups, including Brazilian, French-Canadian, Italian, and Arabs from the United Arab Emirates [20], [21], [22], whereas c.318A>G mutation in subjects K10-1 was previously reported in Asian and Caucasians [13], [23],
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The surprising finding of our study is that
2023-05-30
The surprising finding of our study is that human M1 macrophages stimulated by LPS express ALOX15B to high levels. So far 12/15-lipoxygenase activity was only reported for IL-4 stimulated anti-phlogistic M2 macrophages [9] but not for the classically activated M1 macrophages. Our data suggest that s
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