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br Acknowledgements MC and PD
2024-01-08
Acknowledgements MC and PD were funded by the Michael J Fox Foundation (Grant ID 9969). We would like to thank Pierluigi Saba, Francesco Traccis and Barbara Tuveri for their technical assistance. Introduction In the prostate, androgens play a crucial role in normal, BPH and cancerous growth b
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In recent years the higher
2024-01-08
In recent years, the ‘higher lipophilicity’-thus-‘better performance’ tenet, derived from the polar paradox theory applied to micro-structured media, was challenged by novel and unexpected experimental results. In particular, the synthesis of many complete series of fatty RF 9 esters of natural anti
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br Materials and methods br Results br Discussion br
2024-01-05
Materials and methods Results Discussion Conclusions These studies provide important mechanistic insights to explain the long-established physiological observation that obese adipose tissue has higher rates of basal lipolysis. Increased lipolysis contributes to increased hepatic 8-Hydrox
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Furthermore our lab previously reported that cadmium
2024-01-05
Furthermore, our lab previously reported that cadmium treatment increased AChE-S and decreased AChE-R variants gene expression, which mediates the cell death observed on basal forebrain cholinergic neurons (Del Pino et al., 2016b). AChE-R decreased expression, which presents a neuroprotective role i
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W146 mg br Autophagy and cell death pathways in ischemic
2024-01-05
Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic W146 mg injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morpholog
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br Experimental br Results and discussion
2024-01-05
Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP
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Indications that HMGA proteins are involved in regulating
2024-01-04
Indications that HMGA proteins are involved in regulating the structure and function of large chromatin domains come from the early work of Saitoh and Laemmli [143]. Employing immunolocalization techniques, these workers demonstrated that HMGA1 proteins are co-localized with both histone H1 and the
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Introduction According to Uganda s Ministry of Health MOH
2024-01-04
Introduction According to Uganda's Ministry of Health (MOH 2012a:91), intermittent preventive treatment (IPT) to avoid malaria during pregnancy is a free preventive service available to all pregnant women without clinical signs and symptoms of malaria, attending prenatal clinics. However, pregnant
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The renin angiotensin system RAS is a hormonal system which
2024-01-04
The renin-angiotensin system (RAS) is a hormonal system which plays a role in the regulation of blood pressure and body fluid BI-7273 [14]. The main bioactive peptide of RAS is angiotensin II (Ang II) whose biological functions are interposed through angiotensin type 1 receptor (AT1R) and angiotens
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irak pathway Fig shows a possible scheme of the
2024-01-04
Fig. 8 shows a possible scheme of the generation of AP(+)-exosomes based on this study. In response to inflammatory stimuli, ERAP1 is secreted from ER into the extracellular milieu through the conventional secretion pathway. On the other hand, exosomes are derived from the endosomal pathway, and are
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br Discussion The present understanding is that patients
2024-01-04
Discussion The present understanding is that patients suffering from AD are at a higher risk for epilepsy than individuals without AD [[1], [2]]. The clinical diagnostic accuracy of AD has improved significantly during the last decades. However, most of the epidemiological studies on these two of
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Since pyrrolopyrimidine dithiolanes and both displayed parti
2024-01-04
Since pyrrolopyrimidine dithiolanes and both displayed particularly excellent levels of ACK1 inhibition, these analogs were viewed as potential candidates for further investigation in tumor xenograft experiments. While in vitro metabolic studies indicated that pyrrolidine was predicted to be sign
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br Conclusion Growth survival and invasion of most
2024-01-04
Conclusion Growth, survival, and invasion of most PCs have been shown to be androgen-dependent at the onset of castration therapy [31]. Thus, castration therapy has been central to systemic therapy and remains the standard approach to PC treatment. Even after progression to a castration-resistant
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Because serum ATX activity and plasma
2024-01-04
Because serum ATX activity and NT157 LPA are well correlated with liver fibrosis stage histologically, both of these parameters merit consideration as novel markers of fibrosis. However, serum ATX activity may be a more useful test from a clinical laboratory perspective. First, LPA can increase mar
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Over the past decade extensive research has been
2024-01-04
Over the past decade, extensive research has been directed toward the discovery of Aurora-selective small-molecule inhibitors. As a result, a handful of Aurora inhibitors has been identified. Among them, 1 (VX-680) and 2 (SNS-314) have entered human clinical trials as pan-Aurora kinase inhibitors (F
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